Opioid-Related Disorders Clinical Trial
Official title:
Biobehavioral Study of Opioid Drug Seeking Behavior: Study 3
The purpose is to study how certain factors, including money, the amount of drug available and the amount of work effort, affect opiate drug choice.
A drug dependent person chooses to take drug more often (and suffer its long-term bad
consequences) than choosing to engage in healthy activities (which have better long-term
consequences). The present research will be conducted in a controlled laboratory setting
with heroin abusers who are not seeking treatment to understand what factors guide their
choices.
This research focuses on environmental (i.e. non-medication) factors that affect choosing a
drug versus money. Findings from this research are likely to be important in developing a
theoretical and practical basis for behavioral interventions as part of drug abuse
treatment. HYD is a drug that is currently used as a cough suppressant and to relieve pain.
Participants in this observational study will take part in multiple trials in which they
have the opportunity to choose HYD or money. On the first two experimental days, prior to
choice sessions, participants will receive a sample of the drug doses that can be chosen.
During test sessions, participants will have 12 opportunities to choose either drug or
money. Participants will use a computer to earn choices. Respiration rate, oxygen
saturation, heart rate, and blood pressure will be monitored throughout choice trials.
Self-report questionnaires will be completed at different times during the study.
Participants will be maintained on buprenorphine throughout the study, with a minimum 2-week
lead before the experiment, and a fixed 3-week detoxification after study completion.
;
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT03950492 -
Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder
|
N/A | |
| Completed |
NCT00000335 -
Activity Monitoring Assessment of Opiate Withdrawal - 4
|
Phase 2 | |
| Active, not recruiting |
NCT03949764 -
The Kentucky Viral Hepatitis Treatment Study
|
Phase 4 | |
| Enrolling by invitation |
NCT06084221 -
Fatal Overdose Review Teams - Research to Enhance Surveillance Systems
|
N/A | |
| Completed |
NCT02978417 -
Feasibility Study of Extended-release Naltrexone (Vivitrol) in Drug Court Settings
|
Phase 4 | |
| Withdrawn |
NCT03137017 -
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
|
Phase 1 | |
| Withdrawn |
NCT03137030 -
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults
|
Phase 1 | |
| Completed |
NCT02282306 -
Phone Interview to Prevent Recurring Opioid Overdoses
|
N/A | |
| Completed |
NCT00710385 -
Abuse Liability of Suboxone Versus Subutex
|
Phase 3 | |
| Completed |
NCT00142935 -
Effectiveness of Opiate Replacement Therapy Administered Prior to Release From a Correctional Facility - 1
|
N/A | |
| Completed |
NCT00218309 -
Effects of Pre-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals
|
Phase 2 | |
| Terminated |
NCT00000243 -
Effects of Buprenorphine/Naloxone in Treating Opioid Dependent Individuals Who Are Maintained on Methadone
|
N/A | |
| Completed |
NCT00067184 -
Fetal Neurobehavioral Development in Methadone Maintained Pregnancies
|
||
| Completed |
NCT00000264 -
Subjective/Psychomotor/ Effects of Combined Alcohol & Nitrous Oxide - 16
|
N/A | |
| Completed |
NCT00000257 -
Effects of Alcohol History on Effects of Nitrous Oxide - 9
|
N/A | |
| Completed |
NCT00000306 -
Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3
|
Phase 2 | |
| Completed |
NCT00000279 -
Novel Medications for Opiate Detoxification - 4
|
Phase 2 | |
| Completed |
NCT00000249 -
Effects of Subanesthetic Concentrations of Nitrous Oxide - 1
|
Phase 2 | |
| Recruiting |
NCT04933084 -
Pre-operative Education Modalities to Decrease Opioid Use
|
N/A | |
| Recruiting |
NCT03610672 -
Mobile Intervention for Young Opioid Users
|
N/A |