The Effectiveness of Deep Brain Stimulation for Opioid Relapse Prevention

Status Recruiting

Clinical Trial Summary

The nucleus accumbens (NAcc) has a significant role in the process of opiate addiction and the initiation of relapse after detoxification. There is evidence that deep brain stimulation (DBS) of the NAcc exerts a positive effect on individuals with severe heroin addiction via inhibitory action .

The investigators hypothesise that bilateral stimulation of the NAcc will significantly reduce withdrawal symptoms and thus enable the patients to substantially decrease their Levomethadone usage.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02440152
Study type	Interventional
Source	Ruijin Hospital
Contact	ChenCheng Zhang, MD
Email	i@cczhang.org
Status	Recruiting
Phase	Phase 2/Phase 3
Start date	February 1, 2017
Completion date	July 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02539823` - Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans	Phase 2
Recruiting	`NCT01934751` - Effectiveness of a Hospital Addiction Service in Treating Opioid and Alcohol Addiction	N/A
Completed	`NCT00913770` - Models of Screening, Brief Intervention With a Facilitated Referral to Treatment (SBIRT) for Opioid Patients in the Emergency Department	N/A
Completed	`NCT00929253` - Efficacy of Computer Delivered Community Reinforcement Approach (CRA) (Bup II)	N/A
Terminated	`NCT02741076` - Discontinuation vs Continuation of Long-term Opioid Therapy in Suboptimal and Optimal Responders With Chronic Pain	Phase 4
Completed	`NCT03015597` - Pilot Study of Contingency Management for Smoking Cessation	N/A
Completed	`NCT02571400` - Prevalence and Predictors of Prolonged Post-surgical Opioid Use: a Prospective Observational Cohort Study	N/A
Terminated	`NCT00552578` - Buprenorphine as a Treatment in Opiate Dependent Pain Patients	Phase 4
Completed	`NCT00253890` - Insomnia and Drug Relapse Risk	Phase 3
Completed	`NCT02667158` - A Survey to Eval the Relation Between Doctor/Pharmacy Shopping and Outcomes Suggestive of Misuse, Abuse and/or Diversion
Completed	`NCT02667210` - Study to Eval Relation Btw Doctor/Pharmacy Shopping & Outcomes of Misuse, Diversion, Abuse, Addiction by Med Rec Review
Active, not recruiting	`NCT01021566` - Opiate Detoxification Using the Combined Hemoperfusion-hemodialysis	Phase 3
Withdrawn	`NCT01015066` - Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents	Phase 4
Completed	`NCT02660619` - Validation of PRISM-5-Op, Measure Of Addiction To Prescription Opioid Medication
Active, not recruiting	`NCT02751762` - A Prospective Investigation of the Risks of Opioid Misuse, Abuse, and Addiction Among Patients Treated With Opioids for the Treatment of Chronic Pain
Completed	`NCT02657148` - Immediate Postpartum Nexplanon Placement in Opioid Dependent Women
Completed	`NCT02362256` - The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid Antagonism	N/A
Completed	`NCT01605539` - Acute and Short-term Effects of Cannabidiol Admin on Cue-induced Craving in Drug-abstinent Heroin Dependent Humans	Phase 2
Completed	`NCT00204243` - Naltrexone Implants vs. MMT Among Inmates in the Norwegian Correctional Services	Phase 2
Completed	`NCT02667262` - An Observational Study to Develop Algorithms for Identifying Opioid Abuse and Addiction Based on Admin Claims Data