Differential Lung Ventilation vs. CPAP

Continuous Positive Airway Pressure Clinical Trial

Official title: Differential Lung Ventilation vs. CPAP During One Lung Ventilation for Video Assisted Lung Surgery

Status Completed

Clinical Trial Summary

In this study we compared the efficacy of continuous positive airway pressure (CPAP) to differential lung ventilation, in terms of patient's oxygenation, during video assisted thoracoscopic lung resection.

Clinical Trial Description

Background: One Lung Ventilation (OLV) is the technique used during lung resection surgery in order to facilitate optimal surgical conditions. OLV may result in hypoxemia due to the shunt created. Several techniques are used to overcome the hypoxemia, one of which is continuous positive airway pressure (CPAP) to the non-dependent lung. Another technique is ventilating the non-dependent lung with a minimal volume, thus creating differential lung ventilation (DLV). In this study we compared the efficacy of CPAP to DLV during video assisted thoracoscopic lung resection.

Patients and Method: This is a prospective study of 30 adult patients undergoing elective video assisted thoracoscopic lung lobectomy. Each patient was ventilated in four modes: two lung ventilation, OLV, OLV+CPAP and OLV+DLV. Fifteen patients were ventilated with CPAP first and DLV next, and the other 15 were ventilated with DLV first and then CPAP. Five minutes separated each mode, during which the non-dependent lung was open to room air. We measured the patient's arterial blood gas during each mode of ventilation. The surgeons, who were blinded to the ventilation technique, were asked to assess the surgical conditions at each stage. ;

Related Conditions & MeSH terms

• Continuous Positive Airway Pressure
• Differential Lung Ventilation
• One Lung Ventilation

• NCT number: NCT03563612
• Study type: Interventional
• Source: Rambam Health Care Campus
• Status: Completed
• Phase: N/A
• Start date: April 1, 2017
• Completion date: September 30, 2017