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Clinical Trial Summary

Intratumour heterogeneity is well recognized in multiple cancer types and ultimately leads to therapeutic resistance. It also limits the ability of small samples to represent the whole tumour, having implications for diagnosis, molecular analysis and understanding of the tumour immune microenvironment. By blending- 'homogenizing'- leftover tumour tissue in excess of that required for diagnosistic purposes, one may create a more representative sample for analysis.


Clinical Trial Description

In order to establish the feasibility of homogenization as a potential companion diagnostic tool, our study aims to 1) evaluate how many surgical cases have left over tissue amenable to homogenization and 2) pilot homogenization across multiple tumour types. The molecular profile of the homogenate will be compared to that obtained from the diagnostic specimen using next generation sequencing techniques. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03832062
Study type Observational
Source Royal Marsden NHS Foundation Trust
Contact Samra Turajlic
Phone 0207 811 8576
Email Samra.Turajlic@rmh.nhs.uk
Status Recruiting
Phase
Start date September 10, 2018
Completion date September 30, 2025

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