Omega-3 Fatty Acids Clinical Trial
Official title:
Effect of High Omega-3 Fish Intake on Lipid Peroxidation
NCT number | NCT01183520 |
Other study ID # | GFHNRC017 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | September 2010 |
Est. completion date | December 2012 |
Verified date | January 2022 |
Source | USDA Grand Forks Human Nutrition Research Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The overall goal of this project is to identify an appropriate level of high omega-3 fish (salmon) consumption that will promote optimal omega 3 nutritional status without increasing the level of lipid oxidation in the body.
Status | Completed |
Enrollment | 30 |
Est. completion date | December 2012 |
Est. primary completion date | December 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 60 Years |
Eligibility | Inclusion Criteria: - BMI 25-34.9 - Non-smoker - Free of major medical conditions - Willing to comply with protocol requirements Exclusion Criteria: - Use of lipid modifying drugs or supplements - Taking fish oil or flax supplements - Regular fish consumer - Planning to gain to lose weight - Pregnant or lactating |
Country | Name | City | State |
---|---|---|---|
United States | USDA ARS Grand Forks Human Nutrition Research Center | Grand Forks | North Dakota |
Lead Sponsor | Collaborator |
---|---|
USDA Grand Forks Human Nutrition Research Center | United States Department of Agriculture (USDA), University of North Dakota |
United States,
Holman RT. Control of polyunsaturated acids in tissue lipids. J Am Coll Nutr. 1986;5(2):183-211. Review. — View Citation
Raatz SK, Bibus D, Thomas W, Kris-Etherton P. Total fat intake modifies plasma fatty acid composition in humans. J Nutr. 2001 Feb;131(2):231-4. — View Citation
Roberts LJ 2nd, Fessel JP. The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation. Chem Phys Lipids. 2004 Mar;128(1-2):173-86. Review. — View Citation
Roberts LJ 2nd, Montine TJ, Markesbery WR, Tapper AR, Hardy P, Chemtob S, Dettbarn WD, Morrow JD. Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem. 1998 May 29;273(22):13605-12. — View Citation
Song WL, Paschos G, Fries S, Reilly MP, Yu Y, Rokach J, Chang CT, Patel P, Lawson JA, Fitzgerald GA. Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation. J Biol Chem. 2009 Aug 28;284(35):23636-43. doi: 10.1074/jbc.M109.024075. Epub 2009 Jun 11. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Long chain omega-3 fatty acid (n-3) | Effect of different levels of n-3 intake on n-3 fatty acids in plasma lipoproteins, cell and tissue lipids (cell enrichment) | 6 months | |
Secondary | lipid peroxidation | Effect of different levels of n-3 intake on lipid peroxidation | 6 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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