| Eligibility |
Inclusion Criteria:
- Provide written, informed consent to participate
- Aged = 18 years at time of consent
- Confirmed advanced oesophageal cancer for which the patient must have received at
least one prior line of standard of care treatment
- Predicted life expectancy = 3 months
- Eastern Cooperative Oncology Group (ECOG) PS 0 or 1
- Measurable disease, as defined by RECIST v1.1.
- In the investigator's opinion, have an accessible and biopsiable tumour lesion for
additional research biopsy, to which the patient will have to consent at screening.
- Adequate hematologic and organ function, defined by:
- ANC = 1500 cells/µL (no GCSF support 2 weeks prior to trial entry)
- Platelet count = 100,000/µL
- Haemoglobin = 9.0 g/dL
- AST or ALT = 2.5 times the upper limit of normal (ULN), (except patients with
documented liver metastases where AST and/or ALT can be = 5×ULN)
- Serum bilirubin =1.5 × ULN. (Except patients with confirmed Gilbert's syndrome)
- INR and APTT = 1.5×ULN.
- Calculated creatinine clearance (CrCl) = 40 mL/min (Cockcroft-Gault formula)
- Negative pregnancy test in women of child-bearing potential or evidence of
postmenopausal status
Exclusion Criteria:
- Weight of =30kg
- Any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer
treatment.
- Participation in other clinical trials involving active treatment for the malignant
disease.
- Received radiotherapy treatment on a wide body field, or an equivalent to more than
30% of the bone marrow, within the last 4 weeks.
- Any unresolved symptom NCI CTCAE Grade =2 from previous anticancer therapy (with the
exception of alopecia and vitiligo).
- Active or prior documented autoimmune or inflammatory disease (except vitiligo) within
the last 3 years, for example:
- Intestinal: Inflammatory Bowel Disease (Colitis, Crohn's Disease), Diverticulitis
(with the exception of Diverticulosis), Coeliac Disease, Irritable Bowel Disease
- Vascular: any type of Vasculitic disorder, i.e.: Wegner syndrome.
- Endocrine: any endocrine alteration related to an auto-immune process i.e.:
Hashimoto syndrome. NOTE: patients with hypothyroidism (eg, following Hashimoto
syndrome) stable on hormone replacement treatment may be included at the
discretion of the CI.
- Respiratory: Active Pneumonitis (of any origin: inflammatory or infectious),
Sarcoidosis.
- Dermatological: Psoriasis, Lupus/SLE.
- Other: Rheumatoid Arthritis, Hypophysitis, Uveitis.
- History of organ transplant that requires use of immunosuppressive medications or any
medical condition in which immunosuppressive agents were administered, including but,
not limited to:
- Systemic corticosteroids.
- Methotrexate, azathioprine
- Tumour necrosis factor alpha (TNF-a) blockers
- History of active primary immunodeficiency.
- Receipt of live, attenuated vaccine within the last 30 days.
- Other invasive malignancy within the last 3 years. Patients with previous history of
malignancies with a negligible risk of metastasis or death and treated with expected
curative intent are eligible at the investigator's discretion, for example:
- Carcinoma in situ of the cervix
- Basal or squamous cell skin cancer
- Localized low to intermediate risk prostate cancer treated with curative intent
and absence of prostate-specific antigen (PSA) relapse; or prostate cancer (Stage
T1/T2a, Gleason = 6 and PSA < 10 ng/mL) undergoing active surveillance and
treatment naive
- Women who are pregnant or lactating/ breast feeding.
- Male or female patients with reproductive potential who are not willing to employ
effective birth control from screening to 90 days after the last dose of durvalumab.
- Uncontrolled intercurrent illness, including but not limited to, on-going or active
infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable
angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic
gastrointestinal conditions associated with diarrhea or psychiatric illness/social
situations that would limit compliance with study requirement, substantially increase
risk of incurring AEs or compromise the ability of the patient to give written
informed consent.
- Brain metastases unless asymptomatic, treated and stable and not requiring steroids in
the last 4 weeks. Patients with known or suspected brain metastases at screening
should have a CT/ MRI of the brain prior to trial entry.
- History of leptomeningeal carcinomatosis.
- Active infection or use of antibiotics (ATB) 14 days prior to Cycle 1 Day 1 of
treatment. Patients receiving prophylactic treatment are eligible.
- Active infection including tuberculosis (clinical history, physical examination and
radiographic findings, and TB testing in line with local practice), hepatitis B (known
positive HBV surface antigen (HBsAg) result), hepatitis C, or known human
immunodeficiency virus (positive HIV1/2 antibodies).
- Subjects with a past or resolved HBV infection (defined as: presence of hepatitis
B core antibody -anti-HBc- and absence of hepatitis B surface antigen -HbsAg-)
are eligible.
- Subjects positive for hepatitis C (HCV) antibody are eligible only if polymerase
chain reaction is negative for HCV RNA.
- Major surgical procedure (investigator defined) within 4 weeks prior to first dose or
anticipation of the need for a major surgical procedure during the course of the trial
other than for diagnosis.
- History of severe allergic, anaphylactic, or other hypersensitivity reactions to
durvalumab or any of its excipients, chimeric or humanized antibodies or fusion
proteins.
- Patients previously treated with immune (checkpoint inhibition) therapy
- Any medical condition that would, in the investigator's judgment, prevent the
patient's participation in the clinical trial due to safety concerns, compliance with
clinical trial procedures or interpretation of trial results.
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