Regional Blood Flow Clinical Trial
Official title:
Effects of Indomethacin on Retinal and Choroidal Blood Flow in Healthy Volunteers
Prostaglandins (PG) are known to alter regional ocular blood flow and exhibit vasoactive
properties in isolated ocular blood vessels. A variety of animal experiments indicate that
endogenous PGs play a role in the regulation of retinal (RBF) and choroidal (ChBF) blood
flow. There is also evidence that the prostaglandin pathway is involved in the activation of
NO production in humans, however, the mechanisms for interactions between PG and NO in
ocular vasculature are still unclear.
Animal studies suggest that retinal and choroidal blood flow decrease after administration
of indomethacin (a nonspecific cyclooxygenase inhibitor). More recently, it has been shown
that indomethacin injected intravenously decreased optic nerve oxygen tension and reduced
the CO2 reactivity. This is probably the result of decreased blood flow through
vasoconstriction of vessels in the optic nerve. Systemic administration of indomethacin also
diminishes cerebral, renal and mesenteric blood flow by an unknown mechanism. However, no
clinical trials exist so far investigating the effects of indomethacin on ocular blood flow.
Therefore, the aim of this study is to investigate the effect of indomethacin on ocular
blood flow in healthy humans.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind
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