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Obstructive Sleep Apnea - Autonomic and Vascular Exploration — OSAVE  

Obstructive Sleep Apnea Clinical Trial

Official title:
Noctural Pulse Waves Variations in OSA as a Predictor of Autonomic and Vascular Response to CPAP Therapy

Clinical Trial Summary

The goal of this clinical trial is to assess the effect of CPAP withdrawal on vascular and autonomic function in patients with obstructive sleep apnea. The main question it aims to answer is: • Is the pulse wave amplitude index able to predict the impact of sleep apnea treatment withdrawal (continuous positive airway pressure, CPAP) on endothelial function and baroreflex sensitivity? Participants will stop using their CPAP for 2 weeks and the investigators will assess vascular and autonomic function before and after the withdrawal. Researchers will compare endothelial and autonomic function at baseline and after 2 weeks of withdrawal to see if there are differences. Moreover, they will assess the association between pulse wave amplitude drop profile and effect of CPAP withdrawal.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05920083
Study type Interventional
Source University of Lausanne Hospitals
Contact Adrien Waeber, physician
Phone 0041795850028
Email adrien.waeber@chuv.ch
Status Recruiting
Phase N/A
Start date January 2024
Completion date December 2024
View Details
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