Obstructive Sleep Apnea Clinical Trial
Official title:
An 18-year Follow-up Study on Obstructive Sleep Apnoea in a Population-based Cohort
Our research team has established a polysomnography (PSG) quantified population-based paediatric sleep cohort in 2003 for a childhood OSA prevalence study. Subjects were recruited from 13 randomly selected primary schools. All subjects from this original cohort will be invited to join this 18-year follow-up study to repeat the following data collection: questionnaires, anthropometric measurement, sleep study, 24-hour ambulatory blood pressure (ABP) measurement, echocardiography and neurocognitive assessment.
Status | Recruiting |
Enrollment | 248 |
Est. completion date | September 30, 2025 |
Est. primary completion date | September 30, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - Subjects participants from the 2003 cohort Exclusion Criteria: - Neuromuscular disease - Pathological central apnoea - Severe chronic lung disease with documented hypoxaemia or awake oxygen saturation <92% - Chronic respiratory failure (unrelated to OSA) - Acquired upper airway disease/obstruction - Craniofacial abnormalities (e.g. secondary to trauma and malignancy) Other arrangement: - Subjects who have any respiratory illness within 2 weeks of the scheduled follow-up visit will have their assessment re-arranged until they have fully recovered. - Subjects taking medications that may affect sleep, upper airway patency or blood pressure (for example sedatives, stimulants, antihistamines, and cough medicine) within a week from recruitment will also be rescheduled to participate when they are free from medication use for at least 2 weeks. - Subjects with hypertension and are on anti-hypertensive therapy are allowed to continue on their medication and the information will be obtained and recorded during data collection. |
Country | Name | City | State |
---|---|---|---|
China | Prince of Wales Hospital | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
Chinese University of Hong Kong | Food and Health Bureau, Hong Kong |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | OSA status at 18-year follow-up visit | OSA status of the participants at the 18-year follow-up visit | Through study completion, an average of 2 years | |
Secondary | Factors associated with the persistence or the development of OSA in adulthood | Factors associated with the persistence or the development of OSA in adulthood | Through study completion, an average of 2 years | |
Secondary | Ambulatory blood pressure parameters at 18-year follow-up visit | Ambulatory blood pressure parameters as measures of long-term cardiovascular participants of children who had OSA compared to those without OSA | Through study completion, an average of 2 years | |
Secondary | Echocardiographic parameters at 18-year follow-up visit | Echocardiographic parameters as measures of long-term cardiovascular outcomes of participants who had OSA compared to those without OSA | Through study completion, an average of 2 years | |
Secondary | Neurocognitive function at 18-year follow-up visit | Neurocognitive function outcomes as measures of long-term neurocognitive outcomes of participants who had OSA compared to those without OSA | Through study completion, an average of 2 years |
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