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Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea

Obstructive Sleep Apnea Clinical Trial

Official title:
Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea: A Prospective, Randomized, Controlled, Double-Blind Study

Clinical Trial Summary

The aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea.

Clinical Trial Description

Obstructive sleep apnea (OSA) affects millions of people in the U.S., and currently, there is not a well-established, general anesthetic technique that clearly decreases the risk of postoperative respiratory complications in these patients. If OSA patients have significantly decreased postoperative opioid requirements and improved recovery profiles in the PACU, the protocol could have significant implications in defining future standardized general anesthesia recommendations for patients with this disease. Ultimately, the aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea. The objective of this study is to compare the postoperative recovery profile of OSA patients receiving standard Sevoflurane inhaled anesthesia with normal saline infusion versus Sevoflurane combined with a low-dose ketamine infusion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03109418
Study type Interventional
Source University of Alabama at Birmingham
Contact
Status Terminated
Phase Phase 2/Phase 3
Start date June 2, 2016
Completion date September 12, 2018
View Details
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