Inspiratory Muscle Strength Training for Sleep-related Breathing Disorders

Obstructive Sleep Apnea Clinical Trial

Official title: Respiratory Strength Training Mitigates Hypertension and Sleep Fragmentation in Obstructive Sleep Apnea

Status Completed

Clinical Trial Summary

The purpose of the current study is to investigate the effects of a novel breathing training, called inspiratory muscle strength training (IMST), on sleep patterns, breathing and blood pressure for patients diagnosed with mild, moderate and severe sleep apnea.

Clinical Trial Description

Aims of the study:

1. To determine the influence of IMST on resting blood pressure and baroreceptor sensitivity.

2. To determine the effect of IMST on sympathetic nervous system by measuring plasma cathecholamines and nerve recording (MSNA).

Population:

30 subjects aged 30-75 years, who have previously been diagnosed with obstructive sleep apnea, as defined by the National Institutes of Health (National Heart Lung, and Blood Institute) will be included in this study.

Study Protocol:

• Pre-training assessment and overnight sleep study

• 5-10 minutes each day breathing training (IMST) at home using a hand-held device for 6 weeks

• Once weekly laboratory visit

• Post-training assessment and overnight sleep study

Pre- and post-training assessment include blood pressure measurement, body weight, neck circumference, cardiorespiratory monitoring, nerve recording, blood draw and sleep surveys. ;

Related Conditions & MeSH terms

• Apnea
• Obstructive Sleep Apnea
• Sleep Apnea Syndromes
• Sleep Apnea, Obstructive

• NCT number: NCT02709941
• Study type: Interventional
• Source: University of Arizona
• Status: Completed
• Phase: N/A
• Start date: March 2016
• Completion date: October 2017