Obstructive Sleep Apnea Clinical Trial
Official title:
Memory Consolidation in Obstructive Sleep Apnea
The overarching goal of the research proposed here is to test the hypothesis (i) that the
pathophysiological mechanisms of OSA lead to deterioration in sleep-dependent memory
consolidation across memory systems, with the genetic marker APOε4 as a modulator, and (ii)
that CPAP can reverse some or all of these measured memory deficits.
In addition, we are exploring which aspects of OSA (e.g., changes in sleep architecture,
measures of hypoxemia, or the EEG power spectrum) most likely impact sleep-dependent memory
processing.To this end, we are using specific cognitive tasks for which sleep-dependent
memory consolidation processes have previously been demonstrated by our group and others. In
addition, we are carrying out quantitative EEG power spectral analyses, to delineate
abnormal functioning of brain regions with more precision.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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