Obstructive Sleep Apnea Clinical Trial
Official title:
Effects of Continuous Positive Airway Pressure on Heart Remodeling in Patients With Obstructive Sleep Apnea: A Randomized Study With Cardiovascular Magnetic Resonance Imaging
Obstructive sleep apnea (OSA) is independently associated with important heart remodeling that further contributes to overt heart failure. Recent evidences using echocardiogram suggested that continuous positive airway pressure (CPAP) has beneficial effects mainly on left ventricle parameters. However, the evidences regarding the right ventricle are scanty. In addition, no previous studies evaluated morphological and functional characteristics in OSA by magnetic resonance imaging (MRI) as well as the impact of CPAP.
The patients will be recruited from the Sleep Laboratory, Heart Institute (InCor),
University of São Paulo Medical School. Male adults with a sleep study within 1 month
showing severe OSA (>30 events of apnea and hypopnea per hour of sleep) and naive to
treatment will be considered for the study. Age and body mass index matched controls will be
recruited from the hospital staff and their relatives. All volunteers will be previously
screening for the risk of OSA with Berlin Questionnaire. To minimize confounding risk
factors, we will exclude subjects older than 60 years and those with a body mass index (BMI)
>40 kg/m2, diabetes mellitus, hypertension, cerebrovascular disease, valvular heart disease,
renal failure, current or past smoking history, and chronic use of any medication.
Hypertension will be excluded after 3 or more normal blood pressure values (<140/90mm Hg)
obtained on separate occasions with a conventional mercury sphygmomanometer.
Sleep Study. All participants will perform a standard overnight polysomnography. Apnea will
be defined as complete cessation of airflow for at least 10 seconds, associated with oxygen
desaturation of 3%. Hypopnea will be defined as a significant reduction (>50%) in
respiratory signals for at least 10 seconds associated with oxygen desaturation of 3%. The
apnea-hypopnea index will be calculated as the total number of respiratory events (apneas
plus hypopneas) per hour of sleep. Normal values will be considered when the apnea-hypopnea
index will be <5events/hour.
The participants will be randomly assigned to no treatment (control) or treatment with CPAP
for 3 months, according to a computer-generated list of random numbers. At baseline and
after 3 months, the participants will be submitted to cardiac MRI.
Magnetic resonance imaging methods. Participants will perform MRI examination on 1.5 - T GE
CV/i system. Short and long-axis of the heart will be obtained during breath-hold and
triggered on electrocardiogram pulse sequences. The first sequence will be a gradient-echo
(steady-sate free procession) to assess left ventricular (LV) and right ventricular (RV)
morphology and function. The second sequence will be an inversion-recovery prepared
gradient-echo to obtain MDE (10 to 20 minutes after intravenous bolus of 0.2 mmol/Kg of
gadolinium-based contrast). We will use the following parameters: repetition time 3.9/7.1ms,
echo time 1.7/3.1 ms, flip angle 45º/20º, cardiac phases 20/1, views per segment 8/16 to 32,
matrix 256 x 128/256 x 192, slice thickness 8/8mm, gap between slices 2/2mm and field of
view 32 to 38/32 to 38 cm, inversion time none/150 to 250 ms, receiver bandwidth 125/31,25
kHz, number of excitations 1/2.
Blood Samples. Venous blood will be collected from all participants between 8 and 10 AM for
the measurement of glucose, total cholesterol, low-density lipoprotein, high-density
lipoprotein, and red blood cell count.
24-hour blood pressure monitoring. All participants will be submitted to a 24-hour blood
pressure monitoring with a SpaceLabs device (model 90207).
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
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