Clinical Trials Logo
  1. Home
  2. Obstructive Sleep Apnea Syndrome
  3. NCT02687477

PADN to Treat Severe Obstructive Sleep Apnea — PADN-OSA  

Obstructive Sleep Apnea Syndrome Clinical Trial

Official title:
Pulmonary Artery Denervation to Treat Severe Obstructive Sleep Apnea: a Single-center, Prospective, First-in-man Study（PADN-OSA）

Clinical Trial Summary

This project is focused on the treatment of severe obstructive sleep apnea with pulmonary artery denervation (PADN). Although it has now been proved that continuous positive airway pressure (CPAP) is the primary treatment for obstructive sleep apnea, on the other hand, there is evidence that 25 to 50% of patients can not tolerate CPAP.

The investigators previously reported the safety and efficacy of pulmonary artery denervation (PADN) for treatment of pulmonary hypertension. Excessive sympathetic activation play an important role in the occurrence and development of OSA and cause cardiovascular events. It is worth evaluating the feasibility and tolerance of introducing PADN at the severe stage of obstructive sleep apnea. Therefore, the purpose of our study is to evaluate the safety and feasibility of PADN in the treatment of severe OSA.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02687477
Study type Interventional
Source Nanjing First Hospital, Nanjing Medical University
Contact
Status Terminated
Phase N/A
Start date February 2016
Completion date July 21, 2020
View Details
See also
  Status Clinical Trial Phase
Withdrawn NCT05164211 - Didgeridoo Treatment to Improve Pharyngeal Compliance in Obstructive Sleep Apnea-hypopnea Syndrome in Children N/A
Active, not recruiting NCT05049928 - m-Rehab OSA : Impact of a Telerehabilitation Program Associated With CPAP on Severity Markers of Obstructive Sleep Apnea Syndrome N/A
Not yet recruiting NCT04538274 - Trained Patient Involvement to Promote the Resumption of CPAP in Patients Who Have Discontinued Its Use N/A
Completed NCT02967367 - Reliability of Consumer Sleep Trackers in Patients Suffering From Obstructive Sleep Apnea Syndrome N/A
Completed NCT02995837 - CBF and Childhood OSAS
Completed NCT02180672 - Steroids for Pediatric Apnea Research in Kids Phase 3
Recruiting NCT01561677 - Consequences of Obstructive Sleep Apnea Syndrome (OSAS) After Ischemic Subtentorial Stroke. N/A
Completed NCT01808508 - Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome N/A
Completed NCT01193738 - Osteopathy and Obstructive Sleep Apnea Syndrome N/A
Completed NCT01090297 - Continuous Positive Airway Pressure (CPAP) Mode Impact on Clinical Blood Arterial Pressure N/A
Completed NCT00850876 - Heated Humidified Continuous Positive Airway Pressure and Nasal Physiology N/A
Completed NCT00801671 - Russian Study of the Effect of Continuous Positive Airway Pressure (CPAP) in Hypertension Phase 3
Completed NCT02085720 - Prevalence of OSAS in Chinese Elderly and Its CPAP Compliance N/A
Recruiting NCT00874913 - Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) N/A
Completed NCT00156442 - A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate N/A
Completed NCT00222963 - Pilot Study to Assess the Effectiveness of Tonsil and Adenoidectomy (T+A) in Overweight Children and Adolescents N/A
Withdrawn NCT00156455 - Sleep Disordered Breathing in Children With Single Ventricle Physiology N/A
Completed NCT01045499 - LAGB as a Treatment for Morbid Obesity in Adolescents N/A
Withdrawn NCT02559427 - SPA Therapy in the Treatment of Sleep Apnea Syndrome N/A
Completed NCT02522819 - Feasibility Evaluation of CPAP in the Treatment of Obstructive Sleep Apnea Synchrone in the Acute Phase of Stroke N/A