Single Cell Sequencing of Tonsillar Tissue in Children With OSA

Status Recruiting

Clinical Trial Summary

Obstructive sleep apnoea (OSA) in children is a prevalent sleep disorder, and is characterised by repetitive complete or partial upper airway obstruction during sleep. It is an important disease as it is associated with a large spectrum of end-organ morbidities. Adenotonsillar hypertrophy is the commonest cause of OSA in children, however, the cause of the lymphoid tissue hypertrophy in some individuals but not the others remains unknown. To address the cellular heterogeneity and immune cell involvement in adenotonsillar hypertrophy, here, we propose to employ single-cell sequencing analysis to identify the cell-specific expression patterns associated with the disease, which will enhance our understanding of the pathogenesis of tonsillar hypertrophy in children with OSA and may provide directions for development of novel therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05115968
Study type	Observational
Source	Chinese University of Hong Kong
Contact	Kate C Chan, MBChB
Phone	35052840
Email	katechan@cuhk.edu.hk
Status	Recruiting
Phase
Start date	January 1, 2023
Completion date	December 31, 2025

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