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Clinical Trial Summary

This study is researching experimental drugs called trevogrumab and garetosmab (called "study drugs") in combination with another drug, semaglutide (Wegovy®). Part A of the study, the sponsor is only researching trevogrumab. Part B of the study the sponsor is researching trevogrumab, garetosmab, and Wegovy either alone or in different combinations with each other. Part A of the study is focused on healthy participants. Part B of the study is focused on participants with obesity. The aim of Part A of the study is to see how safe and tolerable the study drug is in healthy participants. The aim of Part B of the study is to see how safe and effective the study drug is when combined with Wegovy. Parts A and B of the study are looking at several other research questions, including: - What side effects may happen from taking the study drug - How much study drug is in the blood at different times - Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)


Clinical Trial Description

Part A Healthy Volunteers Part B (starts after treatment for Part A has completed) Participants with Obesity ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06299098
Study type Interventional
Source Regeneron Pharmaceuticals
Contact
Status Active, not recruiting
Phase Phase 2
Start date March 13, 2024
Completion date June 24, 2026

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