Trial for Harm Reduction With Incentives & Vaping E-cigarettes — THRIVE  

Obesity Clinical Trial

Official title: Harm Reduction in Smokers With Obesity: Impact of Contingent Incentives and E-Cigarettes

Status Recruiting

Clinical Trial Summary

The purpose of this study is to provide preliminary information on the effect of electronic nicotine delivery systems (ENDS) provisions and contingent incentives (CI) on smoking in individuals with overweight/obesity who smoke cigarettes (SWO). All participants will be provided information on the comparative risk of ENDS relative to cigarette smoking, and a randomized group of participants will be provided ENDS provisions for 6 weeks. All participants will complete breath samples for 28 days to measure their exhaled carbon monoxide and will either receive fixed incentives for sample completion or receive varying incentives contingent on their carbon monoxide levels. Researchers will compare groups to understand the effect of each condition on smoking-related behavior.

Clinical Trial Description

Individuals with overweight/obesity who smoke cigarettes (SWO) have greatly increased risks of metabolic, cardiac, and pulmonary diseases due to the synergistic effects of tobacco and obesity. Switching to electronic nicotine delivery systems (ENDS) may decrease the risk of negative health outcomes and be a promising approach for SWO. The purpose of this study is to provide preliminary information on the effect of electronic nicotine delivery systems (ENDS) provisions and contingent incentives (CI) on individuals with overweight/obesity who smoke cigarettes (SWO). The primary aim of this study is to examine the effect of ENDS provision on smoking and the effect of the provision of CI provision on smoking. The secondary aims are to assess the effects of ENDS and CI provision on exhaled carbon monoxide (CO), cigarette dependence, intention to quit smoking, and quitting self-efficacy, and to determine whether any changes in weight occurred secondary to the use of ENDS. Evidence of the efficacy of switching to ENDS and the use of CI could be utilized in healthcare settings to reduce the risk of morbidity and mortality among smokers with obesity. ;

Related Conditions & MeSH terms

• Obesity
• Smoking Cessation

• NCT number: NCT06111053
• Study type: Interventional
• Source: Brown University
• Contact: Cara M Murphy, Ph.D.
• Phone: 1 (401) 203-5339
• Email: THRIVE@brown.edu
• Status: Recruiting
• Phase: N/A
• Start date: October 2, 2023
• Completion date: December 31, 2024