Obesity Clinical Trial
Official title:
Evaluation of Milk Polar Lipids on Lipoprotein Metabolism, Inflammation, and Gut Microbiota in Dyslipidemic Adults With Abdominal Obesity
The major objective of this project is to examine whether daily consumption of milk polar lipids (MPLs) influences cardiometabolic risk factors.
Status | Recruiting |
Enrollment | 130 |
Est. completion date | December 2025 |
Est. primary completion date | December 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 70 Years |
Eligibility | Inclusion Criteria: - LDL-C = 130 mg/dL - Waist circumference = 88 cm for women, = 102 cm for men - Aged 40 to 70 years Exclusion Criteria: - Renal disease - Liver disease - Diabetes - Heart disease - Stroke - Cancer - Eating disorders - Thyroid disease - Gut-associated pathologies - Autoimmune diseases - Chronic inflammatory diseases - Scleroderma - Gallbladder disease - Blood clotting disorders - Intravenous drug use - Self-reported pre-menopausal status - Fasting plasma/serum triglycerides >500 mg/dL - Fasting plasma/serum glucose >126 mg/d - Weight changes >10% over last 4 weeks - Oral antibiotics use up to 1 month prior to and during study - Allergy or intolerance to milk products - Taking lipid-lowering medications (e.g., statins, fibrates) - Taking anti-inflammatory medications (e.g., corticosteroids) - Taking medications which primarily affect blood clotting (e.g., warfarin). |
Country | Name | City | State |
---|---|---|---|
United States | University of Connecticut | Storrs | Connecticut |
Lead Sponsor | Collaborator |
---|---|
University of Connecticut | Dairy Management Inc. |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from Baseline Serum LDL Cholesterol at 8 weeks | Measurement of serum LDL cholesterol (mg/dL) at the beginning and end of 8-week intervention arm. | 8 weeks |
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