Clinical Trial Details
— Status: Recruiting
Administrative data
NCT number |
NCT04865965 |
Other study ID # |
STUDY00000139 |
Secondary ID |
|
Status |
Recruiting |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
May 27, 2021 |
Est. completion date |
August 2024 |
Study information
Verified date |
January 2024 |
Source |
Joslin Diabetes Center |
Contact |
Roeland J Middelbeek, MD |
Phone |
617-309-4616 |
Email |
exercise.research[@]joslin.harvard.edu |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
The purpose of this study is to determine the effects of a single bout of exercise on changes
in the genes and small molecules in blood and fat tissue, before and after a bout of
exercise. This research may contribute to a better understanding of the beneficial effects of
exercise on the body.
Description:
The national and international prevalence of both obesity and type 2 diabetes has risen
dramatically over the last few decades, increasing the need for new therapies to treat these
conditions. An established treatment for type 2 diabetes and obesity are regular physical
activity and exercise. It has been shown that one single session of exercise can lead to
adaptations in the blood and in tissues that improve systemic homeostasis overtime; while
acute changes in skeletal muscle also play a critical role in these effects, changes in the
adipose tissue and in the peripheral mononuclear cells (PBMCs) that may also contribute to
this improvement. However, the beneficial effects of exercise on metabolism through these
other tissues have not been intensively investigated.
The investigators hypothesize that a single session of exercise will result in changes to
white adipose tissue, including changes in metabolites and gene expression, as well as
changes in PBMCs, and that these adaptations may play an important role to improve metabolic
homeostasis.
This hypothesis stems from the investigator's animal-based studies, which have led to the
exciting discoveries that 1) exercise training-induced adaptations to subcutaneous white
adipose tissue (scWAT) result in significant improvements in whole-body glucose tolerance and
insulin sensitivity (1), and 2) the mechanism for this effect may be due to auto-, para-, or
endocrine effects of novel exercise-induced circulating factors coming from adipose tissue.
Thus, being able to further understand, and potentially mimick, these exercise-induced
changes to scWAT could lead to novel therapies for obesity and type 2 diabetes.
Given the great interest in exercise mimetics as treatments for diabetes and obesity, it is
essential to determine if a single session of exercise alters metabolites as well as gene
expression in the scWAT in human subjects with obesity. To determine if a single session of
exercise leads to changes in PBMCs, PBMC transcriptomics will be analyzed. This analysis will
determine how exercise affects the number of specific cell types in the blood that can
regulate metabolic health.