Obesity Clinical Trial
Official title:
Effects of Taurine Supplementation Associated With High Intensity Physical Training on Irisin Levels, Energy Expenditure and Body Composition of Obese Women
Verified date | November 2020 |
Source | University of Sao Paulo |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Irisin is a myocin secreted by skeletal muscle in stimulus to physical exercise and has been described as a possible therapeutic tool in the fight against obesity by triggering a cascade of signaling that triggers the expression of genes responsible for the increase in energy expenditure and browning of adipose tissue white cells by activating thermogenesis promoter mitochondrial proteins. Although the science is engaged in the search for evidences about the actions of the irisin, the physical exercise involved and the improvement in the levels of obesity, many mechanisms are still unknown. Since taurine by means of irisin-like pathways also increases energy expenditure, it is believed that taurine supplementation associated with high intensity aerobic physical exercise can optimize the effects of irisin, increasing energy expenditure and improving body composition in obesity.
Status | Completed |
Enrollment | 31 |
Est. completion date | August 1, 2016 |
Est. primary completion date | May 1, 2016 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 25 Years to 45 Years |
Eligibility | Inclusion Criteria: - This study included women with obesity grade I (BMI =30 - =35Kg/m²), sedentary, with no associated comorbidity, convenience sample. Exclusion Criteria: - Women classified as overweight, obesity grade II and grade III (morbid), who present comorbidities associated with obesity (pre-diabetes, diabetes, hypertension, dyslipidemia, cardiovascular diseases and diseases of bone metabolism); smokers; who use hormones, sports supplements and / or weight loss medications. Perform some type of nutritional monitoring followed by diet or weight loss guidelines and that have medical impediment to the practice of physical exercise. |
Country | Name | City | State |
---|---|---|---|
Brazil | Gabriela Batitucci | Ribeirão Preto | SP |
Lead Sponsor | Collaborator |
---|---|
University of Sao Paulo |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes body weight | The body weight was measured by digital balance before and after the intervention | Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention | |
Primary | Changes body composition | The body composition was evaluated through deuterium oxide | Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention | |
Primary | Changes indirect calorimetry | With a gas analyzer (indirect calorimeter), we evaluated the metabolic rate and rest (REE) and oxidation of substrates (lipids and carbohydrates) | Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention | |
Primary | Changes in total cholesterol and lipid fractions | Collected in EDTA tubes, were centrifuged. | Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention | |
Primary | Changes in plasma taurine concentration | Collected in EDTA tubes, were centrifuged and the plasma taurine concentration was evaluated using HPLC (high performance liquid chromatography). | Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention | |
Primary | Changes in plasma irisin concentration | Collected in EDTA tubes, were centrifuged and the plasma irisin concentration was evaluated using Multiplex - Kit Human Myokine Magnetic Bead Panel. | Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention | |
Primary | Changes Food intake | Food registry of 3 days. The quantification of the daily intake of nutrients will still be made using sofware. | Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention | |
Primary | Changes in determination of lactate | Blood samples were collected by manual puncture of the earlobe in previously calibrated and heparinized capillary tubes, stored in eppendorf with sodium fluoride. Analyzed by electrochemical lactate analyser. | Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention | |
Primary | Changes Physical Performance | Maximum effort test, according to Wilder, Brennan e Schotte (1993). | Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention |
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