the Association Between Thyroid Hormones and Metabolic Components in Patients With Obesity

Obesity Clinical Trial

Official title:

the Association Between Thyroid Hormones and Metabolic Components in Patients With Obesity

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04599374
• Other study ID #: THs
• Status: Completed
• Start date: March 1, 2015
• Est. completion date: September 30, 2020

Study information

• Verified date: December 2020
• Source: Shanghai 10th People's Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study collected clinical data of obese patients with euthyroid function, including age, gender, height, weight, BMI, waist circumference, blood pressure, fasting blood sugar, blood sugar 2 hours after sugar load, fasting plasma high-density lipoprotein cholesterol, fasting three acyl glycerin, free iodine thyroid hormone (FT3) and free thyroid hormones (FT4), thyroid stimulating hormone (TSH), follow-up information and etc. Via analyzing the data, the investigators want to investigate the association between thyroid hormones (THs) and metabolic components in obese patients with euthyroid function and to present the cutoff values of THs in order to provide new information for the risk stratification of metabolic syndrome in obese patients with euthyroid function.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 373
• Est. completion date: September 30, 2020
• Est. primary completion date: September 30, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• 1) age ranged from 18-65 years old, 2) BMI over 27.9kg/m2,3)TSH,FT4, and FT3 within the range of 0.38-4.34mIU/L, 10.5-24.4mIU/L, and 2.8-6.3mIU/L, respectively.

Exclusion Criteria:

• secondary cause of obesity such as hypothalamic obesity, Cushing syndrome, and hypophysis dysfunction, etc.,2)pregnancy or location, 3) severe heart, liver and kidney dysfunction

Related Conditions & MeSH terms

• Euthyroid Condition
• Metabolic Syndrome
• Obesity

Intervention

Other:
• no intervention
This study collected data only without any intervention.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Shanghai 10th People's Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	meet the criteria of metabolism in the 2017 Chinese guideline	Abdominal obesity (or central obesity), male abdominal circumference =90cm, female abdominal circumference =85 cm; Hypertension, those who have been diagnosed with hypertension and are in treatment and (or) blood pressure =130/85mmHg (1mmHg = 0.133kPa); Hyperglycemia, those who have been diagnosed with diabetes and are treated and (or) fasting blood glucose =6.1mmol/L or 2h blood glucose =7.8mmol/L after glucose load; Fasting high-density lipoprotein cholesterol (HDL-C) <1.04mmol/L; Fasting triacylglycerol =1.70mmol/L.	2015-2020
Secondary	high uric acid	female patients with uric acid over 360 umol/L and male female patients with uric acid over 420 umol/L	2015-2020
Secondary	FBG=6.1mmol/L	patients with fasting blood glucose 6.1mmol/L or more.	2015-2020
Secondary	BG120=7.8mmol/L	patients with 2 hour blood glucose 7.8mmol/L or more.	2015-2020
Secondary	FINS=24.9 pmol/ml	patients with fasting insulin 24.9 pmol/ml or more.	2015-2020
Secondary	FCP=4.4nmol/L	patients with fasting C-peptide 4.4nmol/L or more.	2015-2020