Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Changes

Obesity Clinical Trial

Official title:

Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Change

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03348566
• Other study ID #: NHS25487541
• Status: Completed
• Start date: February 1, 2015
• Est. completion date: March 1, 2016

Study information

• Verified date: December 2023
• Source: Harvard School of Public Health (HSPH)
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

the investigators tested whether genetic variants near FADS cluster, which were recently identified to be signatures of adaptation to fish- and n-3 PUFAs-rich diet, interacted with these dietary factors on long-term change of body mass index (BMI).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22000
• Est. completion date: March 1, 2016
• Est. primary completion date: March 1, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• 11,323 women of European ancestry.

• Informed consent was obtained from all participants. The DNA extraction methods, quality control measures,

• SNPs genotyping and imputation data are available .

• Both cases and controls with genotyping data are available based on GWASs

Exclusion Criteria:

• participants without genetic data

Related Conditions & MeSH terms

• Body Weight Changes
• Obesity

Intervention

Other:
• fish
fish intkae

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Harvard School of Public Health (HSPH)

References & Publications (2)

Heianza Y, Qi L. Gene-Diet Interaction and Precision Nutrition in Obesity. Int J Mol Sci. 2017 Apr 7;18(4):787. doi: 10.3390/ijms18040787. — View Citation

Qi Q, Chu AY, Kang JH, Huang J, Rose LM, Jensen MK, Liang L, Curhan GC, Pasquale LR, Wiggs JL, De Vivo I, Chan AT, Choi HK, Tamimi RM, Ridker PM, Hunter DJ, Willett WC, Rimm EB, Chasman DI, Hu FB, Qi L. Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ. 2014 Mar 19;348:g1610. doi: 10.1136/bmj.g1610. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	weight changes	long term weight changes: this study measured body weight at baseline (1990) and follow up body weight in 2000. The long term body weight was defined as changes from baseline to follow up endpoint	6-10 years