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Clinical Trial Details — Status: Terminated

Administrative data

NCT number NCT03297333
Other study ID # 16-1208-4C-1
Secondary ID
Status Terminated
Phase N/A
First received
Last updated
Start date October 1, 2017
Est. completion date March 16, 2020

Study information

Verified date July 2019
Source Southern Illinois University Edwardsville
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using cardiac Magnetic Resonance Imaging.


Description:

Exercise-induced weight-loss is one of the most common strategies for reducing excess fat in overweight and obese individuals. Although vigorous intensity may be more favorable promoting positive cardiac adaptations compared to low-moderate intensity, evidence of the positive effects of different exercise modes needs to be explored to allow for realistic comparisons with other strategies. Research using cardiac Magnetic Resonance Imaging that compares the effects of different modes of exercise - matched by exercise energy expenditure - on epicardial adipose tissue and paracardial adipose tissue, and how these interventions modify cardiac function and geometry have not been previously explored in obesity.


Recruitment information / eligibility

Status Terminated
Enrollment 18
Est. completion date March 16, 2020
Est. primary completion date March 16, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 35 Years
Eligibility Inclusion Criteria: - Sedentary - Caucasian - BMI >30 kg/m2 and < 39.9 kg/m2 Exclusion Criteria: - Known cardiovascular, metabolic, pulmonary disease or conditions - Muscular-skeletal injuries - Taking medications that affect endocrine or cardiovascular function - Hypertension - Being engaged in low intensity strength training more than two times per week or moderate-high intensity of any type of frequency - Being pregnant - Cigarette smoking - Having non-removable pieces or devices incompatible with DXA and CMR assessment.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Resistance training
The resistance training group
Aerobic interval training
The aerobic interval training group

Locations

Country Name City State
United States Southern Illinois University of Edwardsville Edwardsville Illinois

Sponsors (1)

Lead Sponsor Collaborator
Southern Illinois University Edwardsville

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Changes in Epicardial adipose tissue (EAT) EAT will be measured using cardiac Magnetic Resonance 2 assessment points: at baseline and week 4
Primary Changes in Vascular Health Atrial stiffness will be measured using a pulse wave analysis 2 assessment points: at baseline and week 4
Secondary Changes in Paracardial adipose tissue (PAT) PAT will be measured using cardiac Magnetic Resonance 2 assessment points: at baseline and week 4
Secondary Changes in Body Composition Body composition will be measured using dual-energy x-ray absorptiometry 2 assessment points: at baseline and week 4
Secondary Changes in Cardiorespiratory Function Cardiorespiratory Function will be measured on a treadmill with a metabolic cart 2 assessment points: at baseline and week 4
Secondary Changes in Muscular Strength Muscular Strength will be assessed by 1 repetition maximum (1RM) test 2 assessment points: at baseline and week 4
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