Obesity Clinical Trial
Official title:
Influences of Physical Activity in the Profile of Trans Fatty Acids in the Serum of Individuals With Body Weight Changes
Introduction: The metabolism of fatty acids in plasma is modulated by their availability in plasma. Individuals with increased weight have increased plasma fatty acids and physical exercise seems to favor the metabolic responses of fatty acid mobilization. Objective: To test the hypothesis that the physical exercise of acute way changes the fatty acids of medium chain of the serum of individuals with increase of the corporal weight. Method: Including 66 women, randomly divided into two groups, control and experiment, overweight, sedentary, and between 18 and 30 years of age. After a 12-hour fast, basal blood collection will be performed. The experiment group, 12 hours after the first collection, will be submitted to a physical exercise session with energy expenditure of 250Kcal. The volunteers in the control and experiment group will make a second blood collection 24 hours after the first one. The fatty acids will be dosed: pelargonic, azelaic, elaidic and oleic by gas chromatography. Intra and intergroup comparisons will be made using the t test for independent and dependent samples, p <0.05.
Randomized clinical trial with accessible population from the School Clinic of the Adventist
Faculty of Bahia, Brazil.
All women enrolled in the Clinical School physiotherapy service with a body mass index (BMI)
above 24.9kg / m2 will be invited to participate in the study. Sixty-six volunteers who met
the inclusion criteria were: age between 18 and 30 years, BMI> 24.9 kg / m2 and sedentarism
included randomly. Women who present cardiovascular disease, metabolic disease, history of
alcoholism or smoking, use of lipid-lowering drugs, corticoids, diuretics, beta-blockers,
contraceptives, hypothyroidism, parenchymal renal diseases or diabetes mellitus will be
excluded.
The women will be divided randomly into two groups, experiment and control, both with 33
volunteers.
Group Exercise After a 12-hour fast, the volunteers will be submitted to a blood collection
in the antecubital vein to measure basal serum triglycerides, total and fractioned
cholesterol, glycemia and insulin. From the values of Glycemia and insulin the values of the
Homa-IR and Homa-Beta index were calculated by the equation proposed by Matthews et al.
After 12 days after the first blood collection, the patients will perform a physical
exercise session on a treadmill. The same will be divided in 3 times: heating, conditioning
and cooling. The heating will be of 7 minutes, the cooling of 5 minutes and the conditioning
time will be the one corresponding to the energy expenditure of 250Kcal with light intensity
based on the perception of Borg effort, that is, in the original scale a value between 9 and
11. For A better understanding of this scale will be done prior to the day of the exercise
accustoming the volunteers to respond adequately when asked about the intensity of the
exercise.
After the physical exercise session they will be instructed to return home and maintain
their usual diet. After 24 hours after the first blood collection the volunteers will return
to the laboratory after a 12-hour fast and will have blood samples collected again. The diet
of the two days before the blood test will be evaluated through the 24-hour food recall.
Group control The women in the control group will be submitted to the same data collection
protocol of the experimental group, but will not perform exercise 12h after the first
collection and will be instructed not to perform physical exercise in the two days prior to
blood collection.
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