High Intensity Interval Training and Hypoxic Conditioning in Obese Patients

Obesity Clinical Trial

— HYPINT  

Official title:

New Treatment Modalities in Obese Patients: High Intensity Interval Training and Hypoxic Conditioning

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02642705
• Other study ID #: 2014-A01482-45
• Status: Recruiting
• Phase: N/A
• Start date: September 2015
• Est. completion date: April 2021

Study information

• Verified date: March 2020
• Source: University Hospital, Grenoble
• Contact: Samuel Verges, PhD
• Phone: 0476766860
• Email: sverges[@]chu-grenoble.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present study aims at evaluating the effect of two innovative treatment strategies in obese patients: high intensity interval training and hypoxic conditioning. Obese patients will be randomized in groups performing high intensity interval training, constant load training, hypoxic conditioning or placebo normoxic conditioning for 8 weeks. The effects of the interventions will be measured regarding exercise tolerance, blood pressure, body composition, metabolic status.

Description:

120 obese patients will be randomized to 6 intervention groups. Each group will follow an 8-week intervention (3 session per week) with either high intensity interval training in normoxia or hypoxia, constant load exercise training in normoxia or hypoxia, hypoxic or normoxic (placebo) conditioning at rest. Exercise capacity, metabolic status, blood pressure, vascular function and physical activity will be assessed before and after the intervention.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 120
• Est. completion date: April 2021
• Est. primary completion date: April 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• BMI between 27 and 35 kg/m²

• Physical activity <2 hours/week

• No chronic disease or treatment able to interfere with inflammation and metabolic perturbatiosn associated with obesity

Exclusion Criteria:

• Diabetes mellitus treated with insulin

• Auto-immune or inflammatory diseases requiring long term therapy

• Unstable dysthyroidism

• Bariatric surgery within the past 18 months

• Tumoral, inflammatory, infectious, cardiac, respiratory, kidney, digestive disease

• Untreated sleep apnea

Related Conditions & MeSH terms

• Hypoxia
• Obesity

Intervention

Other:
• High intensity interval training N
Exercise training and ambient air breathing
• High intensity interval training H
Exercise training and hypoxic breathing
• Constant load exercise training N
Exercise training and ambient air breathing
• Constant load exercise training H
Exercise training and hypoxic breathing
• Hypoxic conditioning at rest
Hypoxic breathing at rest
• Normoxic conditioning at rest
Normoxic breathing at rest (placebo)

Locations

Country	Name	City	State
France	Grenoble University Hospital	Grenoble	Rhone Alpes

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

Country where clinical trial is conducted

France, 

References & Publications (2)

Verges S, Chacaroun S, Godin-Ribuot D, Baillieul S. Hypoxic Conditioning as a New Therapeutic Modality. Front Pediatr. 2015 Jun 22;3:58. doi: 10.3389/fped.2015.00058. eCollection 2015. Review. — View Citation

Weston KS, Wisløff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med. 2014 Aug;48(16):1227-34. doi: 10.1136/bjsports-2013-092576. Epub 2013 Oct 21. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximal exercise capacity	Maximal oxygen consumption during an incremental exercise test	8 weeks
Secondary	Metabolic status	Blood lipids, glycemia, HOMA index, oxydative stress and inflammatory status	8 weeks
Secondary	Body composition	MRI fat free mass and adipose tissue measurements	8 weeks
Secondary	Blood pressure	24 h ambulatory blood pressure mesurement	8 weeks
Secondary	Vascular function	Post-ischemic hyperemia (Endo-Pat) and pulse wave velocity	8 weeks
Secondary	Physical activity	Spontaneous physical activity measured by accelerometry	8 weeks