Obesity Clinical Trial
Official title:
Natriuretic Peptides and Metabolic Risk in Obesity
The investigators are examining:
1. the relationships of insulin levels and natriuretic peptide hormone levels, and
2. the effects of administering an infusion of natriuretic peptide hormone on the breakdown
of fat
in healthy lean and otherwise healthy obese individuals.
The cardiac natriuretic peptide hormonal system may protect against the development of
cardiometabolic risk. Epidemiologic studies have shown that in relatively healthy individuals
without heart failure, low natriuretic peptide levels are associated with unfavorable
cardiometabolic phenotypes, including higher blood pressure, obesity, higher insulin levels,
and diabetes mellitus. Understanding the mechanisms behind the "natriuretic peptide
deficiency" of obesity would illuminate an important way in which obesity interacts with the
cardiovascular system.
The investigators propose a prospective cross-over design in 40 healthy lean and otherwise
healthy obese individuals. The investigators propose the following specific aims and
hypotheses:
Aim 1: To study the effect of hyperinsulinemia on the response of the natriuretic peptide
system to salt loading.
Hypothesis 1: Hyperinsulinemia will suppress natriuretic peptide levels in both obese and
lean individuals.
Aim 2: To examine the effect of an intravenous infusion of natriuretic peptide on acute
markers of lipolysis.
Hypothesis 2: An intravenous infusion of natriuretic peptide will raise acute markers of
lipolysis in both obese and lean individuals.
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