The Acute Effect of Exercise on Appetite Appetite-regulating Hormones and Inflammation in Children

Obesity Clinical Trial

Official title:

The Acute Effect of High Intensity Exercise on Appetite, Appetite-regulating Hormones, and Bio-markers of Inflammation and Stress in Lean and Obese Boys

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02619461
• Other study ID #: HIT_Exercise_Appetite_001
• Status: Completed
• Phase: N/A
• First received: May 27, 2015
• Last updated: November 29, 2015
• Start date: August 2014
• Est. completion date: October 2015

Study information

• Verified date: November 2015
• Source: University of Toronto
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: 'Canadian Institutes of Health Research'
• Study type: Interventional

Clinical Trial Summary

This study describes the effect of acute high intensity exercise at 70% VO2peak on inflammation, stress, appetite hormones and appetite in lean and obese children and adolescents.

Description:

In summary, exercise does induce a variety of metabolic mechanisms on a central and peripheral level, related to appetite other than solely gut peptides. The literature points towards a rather loose coupling when it comes to high intensity exercise and the suppression of food intake, without a clear explanation of the cause of exercise induced anorexia. This study is aimed to investigate high-intensity exercise and its effects on appetite and satiety hormones, inflammation, stress and eating behaviors on appetite and food intake.

The objective of the current study is to investigate the factors contributing to exercise-induced anorexia in lean and obese children, and maximize its translation into post-exercise suppression of food intake and promotion of negative energy balance particularly in obese children. It is hypothesized that high-intensity exercise would promote a greater suppression of food intake through suppression of appetite ratings via physiological mechanisms depending on stress and inflammation rather than gut peptides.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: October 2015
• Est. primary completion date: July 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 10 Years to 18 Years

Eligibility

Inclusion Criteria:

• 11 normal weight and 11 obese boys will be recruited for the study. Lean and obese boys aged 10-18 years, born full-term and with a normal body weight at birth, will be included in the study

Exclusion Criteria:

• Dieters and individuals with lactose intolerance, allergies to milk and dairy products and gastrointestinal problems will be excluded from the study.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Obesity

Intervention

Other:
• Exercise
Exercise at 70%VO2max on a recumbent bicycle for 30 minutes to investigate the effects of exercise at high intensities on appetite and biomarkers of appetite and inflammation.

Locations

Country	Name	City	State
Canada	Department of Nutritional Sciences	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
University of Toronto

Country where clinical trial is conducted

Canada, 

References & Publications (3)

Bozinovski NC, Bellissimo N, Thomas SG, Pencharz PB, Goode RC, Anderson GH. The effect of duration of exercise at the ventilation threshold on subjective appetite and short-term food intake in 9 to 14 year old boys and girls. Int J Behav Nutr Phys Act. 2009 Oct 9;6:66. doi: 10.1186/1479-5868-6-66. — View Citation

Hunschede S, El Khoury D, Antoine-Jonville S, Smith C, Thomas S, Anderson GH. Acute changes in substrate oxidation do not affect short-term food intake in healthy boys and men. Appl Physiol Nutr Metab. 2015 Feb;40(2):168-77. doi: 10.1139/apnm-2014-0188. Epub 2014 Oct 22. — View Citation

Tamam S, Bellissimo N, Patel BP, Thomas SG, Anderson GH. Overweight and obese boys reduce food intake in response to a glucose drink but fail to increase intake in response to exercise of short duration. Appl Physiol Nutr Metab. 2012 Jun;37(3):520-9. doi: 10.1139/h2012-038. Epub 2012 Apr 25. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Appetite as assessed via visual analog scales	Appetite will be assessed via visual analog scales. Each item will be scored from 0-100; 0 not hungry; 100 very hungry	Timeperiod of 2 hours during each study intervention.	No
Primary	Biomarkers of appetite	Biomarkers of appetite will be assessed such as A. Ghrelin; GLP-1; PYY and Leptin	4 timpoints during 2 hours during each study intervention.	No
Primary	Biomarkers of Inflammation	Biomarkers of inflammation will be assessed such as IL-6; IL-1beta; TNF-alpha; CRP	4 timpoints during 2 hours during each study intervention.	No
Secondary	Biomarkers of Stress	Biomarkers of stress will be assessed such as Cortisol and Adrenalin	4 timpoints during 2 hours during each study intervention.	No