Obesity Clinical Trial
Official title:
Assessment of Hypoxia in Adipose Tissue of Subjects With Obstructive Sleep Apnoea
Verified date | February 2017 |
Source | Royal Devon and Exeter NHS Foundation Trust |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.
Status | Completed |
Enrollment | 15 |
Est. completion date | November 2015 |
Est. primary completion date | March 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 90 Years |
Eligibility |
Inclusion Criteria: - men with or without obstructive sleep apnoea Exclusion Criteria: - weight loss interventions - steroid use - active smoking |
Country | Name | City | State |
---|---|---|---|
United Kingdom | NIHR Clinical Research Facility | Exeter | |
United Kingdom | Royal Devon and Exeter NHS Foundation Trust | Exeter |
Lead Sponsor | Collaborator |
---|---|
Royal Devon and Exeter NHS Foundation Trust | University of Exeter |
United Kingdom,
Thorn CE, Knight B, Pastel E, McCulloch LJ, Patel B, Shore AC, Kos K. Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity. Diabetes Metab. 2017 Jan 25. pii: S1262-3636(16)30567-5. doi: 10.1016/j.diabet.2016.12.002. [Epub ahead of print] — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | adipose tissue gene expression of HIF-1alpha | adipose tissue expression of hypoxia related genes | 4 months | |
Primary | pO2 in adipose tissue by Clarke type electrode | Measurement of pO2 by Clarke type electrode | 4 months | |
Secondary | blood flow in adipose tissue by laser Doppler techniques | assessment of tissue blood flow by laser Doppler techniques | 4 months |
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