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Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures

Obesity Clinical Trial

Official title:
Dynamic Effect of Gastrointestinal Hormones on Cerebral Mechanisms Involved in Brain Perception of Food Pictures After Bariatric Surgery

Clinical Trial Summary

This is a cross-sectional study enrolling

- 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB)

- 11 age- and weight-matched female subjects

- 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal

- electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures

- plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are

- to evaluate the effects of RYGB on brain perception of food related visual stimulation

- to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02160379
Study type Observational
Source University of Lausanne
Contact
Status Completed
Phase N/A
Start date January 2011
Completion date March 2012
View Details
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