Obesity Clinical Trial
Official title:
Exploration of the Physiological Effect of GLP-1 in Obese Adults Diagnosed With Obesity Causing Genetic Mutations
The obesity epidemic is attributable to dietary and behavioral trends acting on a person's
genetic makeup to determine body mass and susceptibility to obesity-related diseases.
Furthermore, common forms of obesity have a strong hereditary component and many genetic
pathways that contribute to obesity have already ben identified.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose-stimulated
insulin secretion. However, GLP-1 also acts as an appetite-inhibiting hormone affecting the
appetite center in the hypothalamus. Today, GLP-1 receptor agonists are available for the
treatment of type 2 diabetes, and their treatment potential in obesity is an area of active
research.
The aim of this study is to explore if the appetite inhibiting effect of GLP-1 is intact in
people diagnosed with obesity causing genetic disorders and to investigate the physiological
role of GLP-1 on food intake and appetite regulation in this group.
- Exploration of the physiological role of GLP-1 concerning food intake and appetite
regulation in obese adults diagnosed with obesity related genetic disorders.
- Assessment of the effect of GLP-1 on body composition, bone mineral density, energy
expenditure, cardiac function, glucose tolerance, insulin sensitivity, lipid
concentrations and neuroendocrine function.
- Assessment of the impact of the leptin induced adaptive thermogenesis response in the
weight reduced study participants.
- Investigating the alteration of the composition of gut bacteria as well as subjective
ratings of satiety and hunger before after supplement with GLP-1.
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