Obesity Clinical Trial
— FructoseOfficial title:
The Effect of High Fructose Corn Syrup Feeding in Nonalcoholic Fatty Liver Disease
Verified date | March 2017 |
Source | Washington University School of Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this research study is to learn more about how high fructose corn syrup, a sugar used to sweeten drinks and foods, affects metabolism in obese persons with and without nonalcoholic fatty liver disease. Eligible participants will be studied before and after eating a diet high in high fructose corn syrup or a standard diet (low in high fructose corn syrup) for four weeks.
Status | Completed |
Enrollment | 47 |
Est. completion date | March 2016 |
Est. primary completion date | March 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - IHTG >6.5% or <5% - BMI 30.0-45.0 kg/m² - Sedentary - Consume <10% calories from high fructose corn syrup - Weight stable for previous 3 months Exclusion Criteria: - IHTG 5.1-7.9% - Children - Adults over 65 years - Pregnant - Lactating - Exercise >1.5 hours/week - Hepatitis B or C - Diabetes - History of liver disease - History of alcohol abuse - Severe hypertriglyceridemia (>300 mg/dl) - Smokers - Anemia (Hemoglobin <10mg/dl) - Not weight stable |
Country | Name | City | State |
---|---|---|---|
United States | Washington University School of Medicine | St. Louis | Missouri |
Lead Sponsor | Collaborator |
---|---|
Washington University School of Medicine |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in intrahepatic triglyceride (IHTG) content | Determine the effect of 4-week isocaloric diet high in high fructose corn syrup (HFCS) on IHTG content measured by magnetic resonance spectroscopy (MRS). | 4 weeks | |
Primary | Hepatic lipid metabolism | Determine the effect of 4-week isocaloric diet high in HFCS on hepatic lipid metabolism [de novo lipogenesis, very low density lipoprotein-triglyceride (VLDL-TG) and very low density lipoprotein-Apolipoprotein B100 (VLDL-ApoB) secretion rates] by using stable isotope tracer methods. | 4 weeks | |
Primary | Multi-organ insulin sensitivity | Determine the effect of 4-week isocaloric diet high in HFCS on multi-organ insulin sensitivity by using a one stage hyperinsulinemic euglycemic clamp procedure in conjunction with muscle and adipose tissue biopsies. | 4 weeks | |
Primary | Uric acid metabolism | Determine the effect of 4-week isocaloric diet high in HFCS on uric acid metabolism by measuring post-prandial serum uric acid concentrations and using stable isotope tracer method. | 4 weeks |
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