Study to Investigate Genetic Causes of Severe Early Childhood Onset Obesity. — GECO  

Obesity Clinical Trial

Official title: Study to Identify Rare Genetic Variants Causing Severe Early Childhood Obesity

Status Recruiting

Clinical Trial Summary

This study aims to investigate genetic causes of early childhood obesity.

The investigators will enroll children and young adults with severe early onset obesity (BMI > 99th percentile) diagnosed prior to 6 years of age. The investigators will ask questions about the health and eating behavior of the participants, and perform a brief physical examination. The investigators will collect saliva or blood to perform genetic testing from the participants and invite family members to enroll in the study.

Clinical Trial Description

This is a clinical and genomic study designed to investigate monogenic causes of severe early childhood obesity.

Participants with severe early onset obesity will be identified by screening of the clinical database or referred for the study. These subjects will be invited to participate in the study. After obtaining informed consent, the investigators will obtain history on the proband and the family, and perform a brief examination in addition to collecting genetic material.

Targeted sequencing of genes associated with monogenic and syndromic forms of obesity will be performed using next-generation sequencing. In selected individuals with favorable family history, exome or whole genome sequencing will be performed. Functional analysis of newly identified variants will be performed where possible. ;

Related Conditions & MeSH terms

• Obesity

• NCT number: NCT01998750
• Study type: Observational
• Source: Columbia University
• Contact: Vidhu Thaker, M.D.
• Phone: 212-851-5315
• Email: vvt2114@cumc.columbia.edu
• Status: Recruiting
• Start date: February 2014
• Completion date: December 2030