Flintstone Foods 1

Obesity Clinical Trial

Official title: A Pilot Study on Gastric Layering and Emptying Induced by a Palaeolithic Inspired Meal

Status Completed

Clinical Trial Summary

This exploratory study is designed to compare the gastric layering and rates of emptying and by inference rates of digestion of a Palaeolithic inspired meal and a reference meal. Two types of meals, one high in fruit and vegetables will be used, and one based on WHO nutritional guidelines. Previous data suggests that the former meal releases nutrients more slowly than the latter. On each of two study days, a total of 11 MRI scans will be taken, 1 baseline and 10 post meal, to assess gastric layering and emptying. Participants will also be asked to complete a questionnaire at predetermined times to assess feelings of satiation.

Clinical Trial Description

This study will be led by Dr Alan Mackie at the Institute of Food Research and supported by Dr Paul Malcolm at the Radiology Department at the Norfolk and Norwich University Hospital Foundation Trust (NNUHFT) and meals will be prepared under the supervision of Dr Frances Bligh at Unilever Research.

The recruitment of participants will be carried out by Alan Mackie at the Institute of Food Research in Norwich. Four apparently healthy participants will be recruited onto the study. Apparently healthy male participants with BMI between 19 and 35 will be recruited either by advertisement or identified from the Institute of Food Research (IFR) Human Nutrition Unit (HNU) Volunteer Database.

Preliminary telephone interview with Alan Mackie, the chief investigator will establish inclusion/exclusion criteria of potential participants who respond to the advertisement and/or the invitation letter. Potential participants will be invited to attend an interview at the HNU at IFR to meet the chief investigator to discuss the study protocol, test meals and to ask any question they have about the study. They will then have a minimum of 72 hours to consider their participation. They will be asked to contact the chief investigator if they are still interested and they will not be contacted by anyone from the research team during this time.

After the participant's response, a next visit will be arranged at the IFR HNU to obtain written consent (Annex 4) and complete an MRI safety questionnaire (Annex 10). The consent will be taken by the Chief Investigator or Senior Research Nurse. Participants consent is a requirement of the screening procedure, during which weight, height and blood pressure will be assessed. Enrollment is contingent on a screening questionnaire (Annex 5) and simple screening (urine dipstick), carried out by the HNU research nurse.

If a participant decides to join the study, the appointment will be made for their Study Test Day at the Radiology Department at the NNUHFT.

On each study day participants will be asked to eat their breakfast at home (before 09:00). The breakfast meal should be recorded (Annex 6) so that it can be repeated on the second visit. They may drink water as much as they need but only until 10am. They will subsequently not be allowed any food or drink.

The study involves participants attending the Radiology Department at the NNUHFT on two separate occasions to consume a test meal (allocated at random)and undergoing 11 MRI scans of the abdomen on each of the two test days.

On each day, after initial formalities, including checking the MRI patient safety questionnaire and changing into a surgical gown, each participant will undergo the first MRI scan (baseline measurement) and complete a VAS questionnaire. If the baseline scan shows significant content as a result of consumption of food after 09:00 then the participant will be rescheduled. The participant will then be asked to consume the meal, allocated at random. The meal will be plated out and consumed in an appropriate room adjacent to the MRI facility. Immediately after the meal has been consumed the second MRI scan will be performed with subsequent scans being undertaken as laid out in the protocol. For each measurement the participant will lie on the scanner table positioned beneath the torsophased array surface coil placed over the upper abdomen. A breath hold scan will be performed to determine stomach position before the full imaging session. Each scanning session takes approximately 5 minutes, in between scans the participant will sit just outside the scanner room. The participants will be asked to repeatedly complete a VAS satiety questionnaire. The timing of these will be predetermined and is given in the protocol.

There will be 1 more study day, similar to Day 1, carried out at least 7 days apart with a different test meal on each occasion (in random order). ;

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Obesity

• NCT number: NCT01925053
• Study type: Interventional
• Source: Institute of Food Research
• Status: Completed
• Phase: N/A
• Start date: July 2013
• Completion date: December 2013