Caffein Consumption and Response Inhibition

Obesity Clinical Trial

Official title:

Does Caffeine Consumption Improve Response Inhibition to Food Cues?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01815203
• Other study ID #: PH2013a
• Status: Completed
• Phase: N/A
• First received: March 18, 2013
• Last updated: September 23, 2013
• Start date: March 2013
• Est. completion date: August 2013

Study information

• Verified date: September 2013
• Source: Uppsala University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Sweden: Regional Ethical Review Board
• Study type: Interventional

Clinical Trial Summary

With the abundance of energy-dense foods that are designed for ease of consumption in the current environment, it is of importance to better understand the factors that may undermine the control of energy intake at healthy levels.

One of the factors that is potentially important in response inhibition is caffeine.

The aim is to assess the direct effects of caffeine on response inhibition, using a No Go/Go-task. We will also assess whether the presentation of food cues, i.e. as words or as pictures, modulate response inhibition different in restrained vs. non-restrained eaters.

Description:

In a blinded, randomized cross-over design, participants will receive either a capsule with caffeine or placebo at two separate occasions whereupon study tasks will be performed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: August 2013
• Est. primary completion date: July 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Only males

• 18 = 35 years

• Healthy (self rated)

• Used to drink caffeine

• Used to eat breakfast regularly (= 5 times a week).

• Non-smokers

Exclusion Criteria:

• BMI outside the range of 18,5 = 25

• hypersensitivity for the ingredients of the foods under study

• being a vegan or vegetarian. Participants reported not using products that are artificially sweetened, nor sugar in coffee and/or tea

• Presence of any chronically disease and/or treatment with medication

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Eating Behavior
• Obesity

Intervention

Drug:
• Caffeine
Administration of one gelatin capsule containing 200-300 mg of caffeine with subsequent cognitive tasks and food test.
• Placebo
Administration of placebo with subsequent cognitive tasks and food test.

Locations

Country	Name	City	State
Sweden	Uppsala University	Uppsala

Sponsors (1)

Lead Sponsor	Collaborator
Uppsala University

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Blood sample	Blood glucose assessment in order to confirm fasted condition prior to study experiments.	5 min (1 sample)	No
Primary	Inhibition control	Measurement inhibition control via a computer test (NoGo-Go task.	20 min	No
Secondary	Food test	Measure of participants food intake.	20 min	No