Effect of Beverages Containing Different Doses of Alginate Fibers on Appetite, Energy Intake and Glycemia

Obesity Clinical Trial

— ALSAT  

Official title:

Effect of Beverages Containing Different Doses of Alginate Fibers on Appetite, Energy Intake and Glycemia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01720784
• Other study ID #: H-3-2012-101
• Secondary ID: B295
• Status: Completed
• Phase: N/A
• First received: October 31, 2012
• Last updated: September 1, 2014
• Start date: October 2012
• Est. completion date: July 2013

Study information

• Verified date: September 2014
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: The Danish National Committee on Biomedical Research Ethics
• Study type: Interventional

Clinical Trial Summary

Studies report that dietary fiber intake is inversely correlated with body weight gain. Previously, we have shown alginate fiber supplementation increases weight loss, which we ascribe to its satiating effct.Alginate is a major plant dietary fiber in brown seaweed. One property of importance to appetite is the ability of alginate to gel in the acidic environment of the stomach. We hypothesize that the alginate will decrease the feeling of hunger and lower food consumption compared to control.

Here we test three different beverages in a double-blinded crossover design, in which 24 participants will be randomly assigned to the sequence of the test days separated by at least 5 days.

On each test day appetite sensation as well as blood glucose and insulin will be measured over 4h after intake of the test product. Hereafter, an ad libitum meal consisting of Pasta Bolognese will be served, and energy intake calculated. The participants will also rate gastrointestinal confort.

Description:

Three different iso-caloric beverages will be tested in a double-blinded crossover design, in which 24 participants will be randomly assigned to the sequence of the test days separated by at least 5 days. Prior to the test days, the participants will follow a standardized fasting procedure: abstention from alcohol hard physical activity for 24 h; furthermore, consumption of the same evening meal no later than 8 pm on the night before all meal tests, after which time point they should be fasting. They are allowed 500 mL of water between 8 pm and the morning of the test days.

On each test day, the participants will meet at the department in a fasting state. After voiding they will be weighed, and a venflon catheter will be inserted in the antecubital vein, allowing repeated blood sampling throughout the test day. Baseline measurements of blood pressure, blood samples, and visual analogue scales (VAS) scores will be conducted at time point of -15 min. A second baseline blood sample will be drawn at time point 0, immediately after which the participants will consume the preload beverage (time point 0) with a 10 min time limit for consumption. After consumption of the preload beverage, blood samples will be taken and VAS scores completed at time points 15 and 30 min, and hereafter the he standardized breakfast will be served for which 15 minutes is allowed (time point 30 min). After the participants have finished the breakfast, blood samples will be drawn and VAS scores completed at time points 45, 60, 90, 120, 180, 210 and 240 min.

Hereafter, an ad libitum meal consisting of Pasta Bolognese will be served, and energy intake calculated, and the final VAS score will be completed at time point 270 min after the participants have finished their lunch. Before leaving, the participants will fill in a questionnaire related to gastrointestinal adverse events (AE).

As a pilot study, the first 6 participants to finish the study will be invited to participate in a fourth test day, on which capsules containing alginate fibers will be administered together with the placebo beverage. This fourth test day is not included in the randomization and will not be blinded for the participants.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: July 2013
• Est. primary completion date: March 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• Overweight (BMI 25-35 kg/m2)

Exclusion Criteria:

• Any food allergy, dislike or special diet of relevance to the study (e.g. vegetarian)

• Smoking

• Use of dietary supplements up to 1 month before the first meal test

• Pregnancy or lactation

• Daily use of prescription medication (except for oral contraceptives)

• Any known chronic illnesses

• Participation in other intervention studies

• Non-adherence to the protocol or lack of cooperation

• Blood donation within 3 months prior to the study

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Obesity

Intervention

Dietary Supplement:
• Alginate dietary fiber

• Placebo

Locations

Country	Name	City	State
Denmark	Department of Nutrition, Exercise and Sports, University of Copenhagen	Frederiksberg C

Sponsors (2)

Lead Sponsor	Collaborator
Arne Astrup	S-Biotek Holding A/S

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Ratings of gastrointestinal discomfort during 24 hours following the test meals		Assessed4 times over a 24 hour period after each of three test meals served at least 5 days apart	Yes
Primary	Subjective appetite ratings including derivative measures		Assessed 12 times over a 4hour period after each of three test meals served at least 5 days apart	No
Secondary	Ad libitum food intake at the subsequent meal		Assessed after 4 hours after each of three test meals served at least 5 days apart	No
Secondary	Glucose and insulin response including derivative measures		Assessed 12 times over a 4hour period after each of three test meals served at least 5 days apart	No