Calorie Anticipation and Food Intake

Obesity Clinical Trial

Official title:

Differences in Physiological Responses of Satiety and Reward After (in)Consistent Calorie Cues.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01680315
• Other study ID #: PH2012
• Status: Completed
• Phase: N/A
• First received: August 28, 2012
• Last updated: September 3, 2012
• Start date: May 2012
• Est. completion date: August 2012

Study information

• Verified date: August 2012
• Source: Uppsala University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Sweden: Regional Ethical Review Board
• Study type: Interventional

Clinical Trial Summary

The regulation of our food intake is on the short-term guided by appetite and satiety signals generated by the sight and consumption of food. Food intake is not only regulated by appetite and satiety signals - external cues also play an important role.

It has been observed that food intake and the pleasure derived from consumption is affected by manipulation of the external cues.

The investigators will assess the contribution of food anticipation (calorie information) and actual consumption of a test food (calorie intake) on in satiety responses (such as ghrelin responses, appetite and subsequent food intake). The investigators expect the information on the amount of calories, rather than the actual amount of calories in the food, to predict the ghrelin responses and the subsequent intake of a second meal.

Description:

In a randomized cross-over design with 4 conditions, all participants will consume twice the low-caloric food (once with the low-calorie information and once with the high-calorie information) and twice the high-caloric food (again, once with the low-calorie information and once with the high-calorie information) in a randomized order.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: August 2012
• Est. primary completion date: July 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• female

• healthy

• being used to eat breakfast regularly (= 5 times a week).

Exclusion Criteria:

• hypersensitivity for the ingredients of the foods under study;

• lack of appetite; following an energy-restricted diet or change in body weight > 5 kg; or

• being a vegan or vegetarian. Participants reported not using products that are artificially sweetened, nor sugar in coffee and/or tea.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Eating Behaviour
• Obesity

Intervention

Behavioral:
• low calorie yogurt
all participants consumed twice the low-caloric food (once with the low-calorie information and once with the high-calorie information)
• high calorie yogurt
all participants consumed twice the high-caloric food (once with the low-calorie information and once with the high-calorie information)

Locations

Country	Name	City	State
Sweden	Uppsala University	Uppsala

Sponsors (1)

Lead Sponsor	Collaborator
Uppsala University

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	appetite ratings		80 min (5 samples - every 20 min)	No
Other	Serum cortisol concentrations		60 min (4 samples - every 20 min)	No
Primary	Food intake		60 min (Ad libitum test meal after 1 hr)	No
Secondary	Serum concentrations total ghrelin		60 min (4 samples - every 20 min)	No