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Long-term Investigation of Resveratrol on Fat Metabolism in Obese Men With Nonalcoholic Fatty Liver Disease

Obesity Clinical Trial

Official title:
Long-term Investigation of Resveratrol on Lipid Turnover in Obese Men With Nonalcoholic Fatty Liver Disease. Effects on Liver Fat Content and Basal and Insulin Stimulated FFA and VLDL-triglyceride Metabolism

Clinical Trial Summary

The purpose of this study is to investigate potential metabolic effects of resveratrol in obese healthy men with non-alcoholic fatty liver disease.

The investigators hypothesize that resveratrol will:

- decrease hepatic very-low-density-lipoprotein-triglyceride (VLDL-TG) secretion

- decrease liver fat content

- increase insulin sensitivity

The investigators will look at changes in:

- lipid turnover (VLDL-TG kinetics, palmitate kinetics, indirect calorimetry)

- liver fat content (MR liver spectroscopy)

- insulin sensitivity (glucose kinetics during hyperinsulinaemic euglycaemic clamp)

- body composition (DXA and MRI)

- lipase activity and fat cell size (fat biopsy from abdominal and femoral adipose tissue)

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01446276
Study type Interventional
Source University of Aarhus
Contact
Status Completed
Phase N/A
Start date November 2011
Completion date April 2014
View Details
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