Obesity Clinical Trial
Official title:
Caloric Restriction in Obese Patients With Mild Cognitive Impairment: Effects on Adiposity, Comorbidity and Cognition
Obesity has been associated with cognitive impairments, lower blood flow, metabolic activity and brain volume. Obesity in adulthood is a risk factor for Alzheimer's disease in the elderly. The mild cognitive impairment (MCI) is a condition that may precede dementia. We hypothesized that promotion of weight loss in obese people with MCI, through caloric restriction could lead to improvement in cognitive performance or reduction in the rate of decline and decreased risk of dementia. A sample of 80 patients aged ≥ 60 years, obese, with MCI, will be randomized to two groups that will be followed for 12 months. The control group will receive conventional medical care. The intervention group will receive nutritional counseling individually and in groups, aiming to promote weight loss through caloric restriction, and medical monitoring. Before and after intervention patients will be evaluated for anthropometry, body composition, physical performance, control of comorbidities, laboratory tests (glucose, insulin, lipid profile, leptin, adiponectin, interleukin 6, tumor necrosis factor alpha, CRP), Genotyping apolipoprotein E, neuropsychological battery, questionnaires about activities of daily living, physical activity and diet.
Status | Completed |
Enrollment | 80 |
Est. completion date | October 2014 |
Est. primary completion date | May 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 60 Years and older |
Eligibility |
Inclusion Criteria: - body mass index (BMI) = 30 kg/m2 - independent for most of the instrumental activities of daily life; - literate; - able to walk, - diagnosis of mild cognitive impairment Exclusion Criteria: - weight loss greater than 3 kg over the past two months, - presence of uncontrolled disease that potentially interfere with metabolism and weight gain or whose treatment would influence the cognitive performance, such as major depression, bulimia, hypothyroidism, Cushing's disease, heart failure, neoplasia in the last 3 years, alcoholism, infectious diseases and auto-immune activity; - use of anti-obesity drugs, benzodiazepines, neuroleptics or estrogen replacement therapy in the past 2 months; - previous bariatric surgery, - severe sensory deficit |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Brazil | Hospital das Clínicas - Faculdade de Medicina da USP | Sao Paulo |
Lead Sponsor | Collaborator |
---|---|
University of Sao Paulo General Hospital | Fundação de Amparo à Pesquisa do Estado de São Paulo |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Neuropsychological test performance | Montreal Cognitive Assessment (MoCA), Mini Mental State Examination (MMSE), Subjective Memory Complaints scale and CAMcog from CAMDEX (The Cambridge Examination for Mental Disorders of the Elderly, The Rivermead Behavioural Memory, The Wisconsin Card Sorting Task, trail making test part A and B, The Rey auditory-verbal learning test, semantic and phonologic verbal fluency test, digits (WAIS-III), vocabulary (WAIS - III), matrix (WAIS - III) | baseline and 12 months | No |
Primary | Diagnosis of dementia | The diagnosis of dementia will be given from the DSM IV TR: The diagnosis of Alzheimer's disease will be defined according to DSM IV. | 12 months | No |
Primary | Weight loss | anthropometry (weight, height, BMI, waist circumference, hip circumference), body composition by bioimpedance | 12 months | Yes |
Secondary | plasma biomarkers | glucose, insulin, lipid profile, leptin, adiponectin, interleukin 6, tumor necrosis factor alpha, CRP | 0 and 12 months | No |
Secondary | Genotyping apolipoprotein E | The genotype is a covariate to assess response to treatment | baseline | No |
Secondary | Charlson comorbidity index | 0 and 12 moths | No | |
Secondary | International physical activity questionnaire- short version (IPAQ) | 0 and 12 moths | No | |
Secondary | Evaluation of Food Consumption | 0 and 12 moths | No | |
Secondary | SPPB- Short physical performance battery | 0 and 12 moths | Yes | |
Secondary | Blood pressure | 0 and 12 moths | No |
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