High-intensity Intermittent Training for Obese Individuals

Obesity Clinical Trial

Official title:

High-intensity Intermittent Training to Maximize Metabolic and Cardiovascular Protection in Obese Individuals

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01143376
• Other study ID #: 2010/447
• Status: Completed
• Phase: N/A
• First received: June 2, 2010
• Last updated: April 19, 2017
• Start date: May 2010
• Est. completion date: January 2014

Study information

• Verified date: April 2017
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The most appropriate and effective exercise interventions for weight loss remain a matter of continued discussion and there is a need to identify sustainable exercise programs which successfully promote weight loss and benefit health.

The primary objective of this study is to determine if high-intensity intermittent sprinting (HIIS) produces better results in terms of reducing metabolic and cardiovascular risk factors, with special emphasis to fat mass loss and insulin sensitivity in "healthy" obese volunteers compared with an iso-caloric program of moderate-intensity continuous cycling (MICC) (control condition following the international recommendations). We will also assess the impact of short duration sprints (SDS) in the above factors and to understand the potential mechanisms behind different outcomes among training programs.

The overall hypothesis is that HIIS will lead to a greater reduction in metabolic and cardiovascular risk factors compared with MICC in healthy obese volunteers and that SDS will produce similar improvements in cardiovascular risk factors as the longer duration HIIS

Description:

Participants will be randomized to one of three groups: HIIS (8s sprint:12s rest) or MICC (control group) iso-caloric protocols (for the duration needed to induce a 250 kcal energy deficit) or SDS (8s sprint:12s rest) for 10 minutes for 12 weeks. The intervention groups will be matched for age, BMI and male/females ratio and participants will be asked not to change their normal diet throughout the study.

Before and after the exercise intervention (12 weeks), participants will perform the following assessments:

1. Three-day food diaries

2. Anthropometric measurements (weight, height, waist and hips) using standard procedures;

3. Body composition using dual energy x-ray absorptiometry (DEXA)

4. RMR and resting respiratory exchange ratio (RER) using indirect calorimetry;

5. Endothelial function assessed by flow-mediated dilation (FMD) of the brachial artery using vascular ultrasound according to current guidelines;

6. Maximal oxygen uptake (VO2max) and fat oxidation, cardiac output and left ventricular function during exercise using a cycle ergometer;

7. Muscle and fat biopsies

8. Fasting and postprandial release of appetite related hormones (and subjective feelings of hunger/fullness using visual analogue scales - VAS).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: January 2014
• Est. primary completion date: December 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• weight stable on the last three months,

• not currently dieting to lose weight

• inactive lifestyle.

Exclusion Criteria:

• History of endocrine/cardiovascular/pulmonary/kidney disease,

• anaemia,

• gout,

• depression or other psychological disorders,

• eating disorders,

• drug or alcohol abuse within the last two years

• current medication known to affect appetite or induce weight loss.

• planned surgery during the study period

• participation in another research study

• restraint score derived from the TFEQ>12

• post-menopausal women

Related Conditions & MeSH terms

• Obesity

Intervention

Behavioral:
• High intensity training
high-intensity intermittent sprinting (HIIS) (8 sec sprint:12 sec rest) for 12 weeks, 4 times a week
• short springs
short duration sprints (SDS)(8 sec sprint:12 sec rest) for 12 weeks, 4 times a week
• Moderate intensity exercise

Locations

Country	Name	City	State
Norway	Norwegian University of Science and Technology	Trondheim

Sponsors (2)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology	Helse Midt-Norge

Country where clinical trial is conducted

Norway, 

References & Publications (2)

Martins C, Aschehoug I, Ludviksen M, Holst J, Finlayson G, Wisloff U, Morgan L, King N, Kulseng B. High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese. Med Sci Sports Exerc. 2017 Apr 11. doi: 10.1249/MSS.0000000000001296. [Ep — View Citation

Martins C, Kazakova I, Ludviksen M, Mehus I, Wisloff U, Kulseng B, Morgan L, King N. High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in body composition	Body composition assessed by DEXA	Baseline and after 12 weeks of training
Secondary	Changes in insulin sensitivity	Insulin will be measured in fasting and for 3h after a test meal	Baseline and after 12 weeks of training