Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure

Obesity Clinical Trial

— MAES  

Official title:

Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01133964
• Other study ID #: B256
• Status: Completed
• Phase: N/A
• First received: May 27, 2010
• Last updated: June 23, 2011
• Start date: October 2008
• Est. completion date: December 2009

Study information

• Verified date: September 2008
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: Ethics CommitteeDenmark: Danish Dataprotection Agency
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to examine the effect of dairy proteins (whey and casein) on postprandial appetite regulation and energy expenditure.

Description:

Several studies have shown that a high protein intake is associated with a increased loss of body weight and body fat as compared to a diet with a normal or low protein content. The effect seems to be due to a higher diet induced thermogenesis and increase satiety.

Milk has a high content of proteins. It contains two very different types of protein: whey and casein. Whey is a soluble protein whereas casein clots into the stomach, which delays its gastric emptying and thus probably results in a slower release of amino acids. It is therefore very likely that the two types of protein affect the thermogenesis and appetite regulation differently.

The aim of the present study is to examine the effect of dairy proteins (whey and casein) on postprandial energy expenditure, substrate oxidation and appetite regulation.

The study will have a cross-over design including four meals each including a test drink (milk, casein drink, whey drink or water).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: December 2009
• Est. primary completion date: December 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• healthy males

• body mass index (BMI) 25-30 kg/m2

• 18-50 years

• weight stable

Exclusion Criteria:

• smoker

• regular use of medicine

• elitist athletes

• participation in other intervention studies

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Obesity

Intervention

Dietary Supplement:
• dairy proteins
Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.

Locations

Country	Name	City	State
Denmark	Department og Human Nutrition, Life, University of Copenhagen	Copenhagen

Sponsors (2)

Lead Sponsor	Collaborator
University of Copenhagen	Arla Foods

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Subjective appetite sensation		5 hours	No
Primary	Energy expenditure		5 hours	No
Primary	Substrate oxidation		5 hours	No