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Sibutramine-metformin Combination Versus Sibutramine and Metformin Monotherapy in Obese Patients

Obesity Clinical Trial

Official title:
Double-blind, Randomized Clinical Trial to Evaluate Effect of Combination Therapy of Metformin and Sibutramine Versus Metformin or Sibutramine Monotherapy Over Weight, Adiposity, Glucose Metabolism and Inflammatory State in Obese Patients

Clinical Trial Summary

The aim of this study is to evaluate the effect of sibutramine and metformin combination therapy in comparison with sibutramine or metformin monotherapy over weight, adiposity, glucose metabolism and inflammatory state in obese patients.

Clinical Trial Description

The treatment of obesity is strongly recommended because it exacerbates insulin resistance, hypertension, dyslipidemia and atherosclerosis, and represents a risk factor for type 2 diabetes. Although diet and exercise are valuable in this treatment, patient compliance is a major problem. Sibutramine has been shown to be a highly effective pharmacotherapy for weigh loss in obese patients, mediated by increased satiety and an enhancement of energy expenditure. Metformin is widely used for glycemia control and is associated with a small to moderate body weight loss. We are assessing the combination of sibutramine and metformin, two agents with different mechanisms of action for control of body weight and metabolic dysregulation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00941382
Study type Interventional
Source Laboratorios Silanes S.A. de C.V.
Contact
Status Unknown status
Phase Phase 3
Start date November 2008
Completion date September 2009
View Details
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