Obesity Clinical Trial
Official title:
Sleep Apnea-Hypopnea Syndrome and the Pathogenesis of Obesity
The hypothesis of the study is the following: Patients with sleep apnea-hypopnea syndrome
have different pattern in the secretion of hormones.
The chronic sleep disorganization that suffer patients with sleep apnea-hypopnea syndrome
(SAHS) may affect the central mechanisms that regulate nutritive behavior and energetic
balance, causing an alteration in the secretion of hormones that favour the appearance
and/or development of obesity.
OBJECTIVES: To compare the plasmatic profiles of different hormones and neuropeptides,
related with weight control, metabolism and intake in patients with SAHS as well as in
selected control subjects according to weight.
DESIGN: Multicenter, prospective and controlled study. 40 patients with SAHS will be
included as well as 40 control subjects.
METHODS: To all subjects included in the study, the following procedures will be performed:
1. Medical History;
2. Anthropometric variables (height, weight, Body Mass Index;
3. Somnolence evaluation using the Epworth scale;
4. Conventional Polysomnography (PSG);
5. Determination every four hours during a 24 hours period of the levels of leptin
adiponectin, resistin, insulin, PCR, etc.
6. Conventional biologic evaluation;
7. Patients will be re-evaluated after three months of treatment with CPAP.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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