Obesity Clinical Trial
Official title:
The CLiFF Study: A Prospective Evaluation of Change in Liver Function and Fat in Patients With Colorectal Liver Metastases Undergoing Pre-operative Chemotherapy
The CLiFF Study will assess changes in liver function and liver fat in patients with
colorectal liver metastases (CLM) undergoing pre-operative chemotherapy before liver
resection. There will be no change to the standard treatment for CLM. The change in liver fat
will be assessed using novel magnetic resonance techniques and the change in liver function
will be measured using a newly-developed fully-licensed breath test to give the most accurate
measure of liver function possible.
Understanding if these changes are related or reversible will help to understand the
relationship between obesity and cancer. This is an important issue, as obesity is now the
second most common cause of cancer worldwide.
Obesity is the second most common cause of cancer in the United Kingdom (UK) and bowel cancer
is the third most common cancer. Obesity can increase both the chance of developing bowel
cancer and it's progression. Increased liver fat is likely to be important in this process,
but it is not easy to measure liver fat accurately without invasive biopsies.
Chemotherapy is often used to treat colorectal liver metastases before surgery. It is known
that chemotherapy can increase liver fat and can reduce liver function, however it is not
known if these changes are either reversible or related.
Understanding the relationship of these changes and their potential reversibility could help
plan the best treatment for colorectal liver metastases and to understand the wider
relationship between obesity and cancer.
A Manchester cancer research team have developed new MR (magnetic resonance) scan techniques
which are better able to measure liver fat levels without needing invasive biopsies. The
researchers also have a newly-developed fully-licensed machine which can measure liver
function more accurately by using a breath test (LiMAx test), donated to the team for this
study by the manufacturer, Humedics GmbH.
Patients undergoing pre-operative chemotherapy for CLM at the Christie Hospital will be
invited to join this study. Their liver fat content will be measured using the new MR
techniques and their liver function measured using the LiMAx test. These will be measured
before chemotherapy, during chemotherapy, and after they finish. Their normal treatment will
remain unchanged. When they undergo liver surgery, the section of removed liver will be
analysed for fatty changes to help confirm that the MR scans are accurate.
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