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Obstructive Sleep Apnoea and Adipose Tissue Dysfunction

Obesity Clinical Trial

Official title:
Assessment of Hypoxia in Adipose Tissue of Subjects With Obstructive Sleep Apnoea

Clinical Trial Summary

Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.

Clinical Trial Description

Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02518633
Study type Observational
Source Royal Devon and Exeter NHS Foundation Trust
Contact
Status Completed
Phase N/A
Start date March 2010
Completion date November 2015
View Details
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