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Different Limb Lengths in Gastric Bypass Surgery (SLIM) - Part 3: Metabolism and Inflammation — SLIM - Part 3  

Obesity, Morbid Clinical Trial

Official title:
Swiss Multicenter Randomized Controlled Trial on Different Limb Lengths in Gastric Bypass Surgery (SLIM Trial) - Part 3: Metabolic Mechanisms and Inflammatory Response

Clinical Trial Summary

Investigation of underlying metabolic mechanisms and impact on the two surgical procedures on inflammatory factors.

Clinical Trial Description

The aim of this project is to investigate underlying metabolic mechanisms in a subpopulation of patients of the SLIM trial, where a laparoscopic proximal Roux-en-Y gastric bypass (LRYGB) with a longer biliopancreatic limb (BPL) is compared to a standard LRYGB. For this purpose, the aim is to examine differences in number of intestinal enteroendocrine cells, subpopulations of intestinal macrophages, and gene expression or DNA-methylation in tissue samples obtained by colonoscopy from the ileum and transverse colon. In addition, gut microbiota (from colon biopsy and fecal samples), meal-stimulated gut hormone profiles, glycemic control, and metabolite patterns (metabolomics; in blood, urine, stool and breath) including plasma bile acid concentrations preoperatively and 6 months post-surgery will be examined. Body composition (fat mass and lean mass) will be measured by means of BIA (bioimpedance analysis; Biacorpus). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05471037
Study type Interventional
Source University Hospital, Basel, Switzerland
Contact Ralph Peterli, Prof. Dr. med.
Phone + 41 61 777 75 01
Email ralph.peterli@clarunis.ch
Status Recruiting
Phase N/A
Start date August 1, 2022
Completion date January 1, 2025
View Details
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