vBloc Now - Registry

Obesity, Morbid Clinical Trial

Official title:

vBloc Now - A Prospective Observational Registry on the Maestro Rechargeable System (vBloc Therapy)

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03434522
• Other study ID #: D01702-000
• Status: Active, not recruiting
• Start date: December 27, 2017
• Est. completion date: May 31, 2019

Study information

• Verified date: February 2018
• Source: EnteroMedics
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is a prospective, observational, case series registry which will collect information pertaining to experiences and health economics in individuals implanted with vBloc Therapy who are conjunctively using a weight management program. Subjects will be followed for 12 months after implant.

Description:

The vBloc is a neuromodulation system that consists of the following implantable and external components:

• Implantable components: Two leads (including one electrode each for the anterior and posterior intra-abdominal vagal nerve trunks) are implanted laparoscopically on the intra-abdominal trunks of the vagus nerve and connected to a neuroregulator, which is implanted subcutaneously on the thoracic sidewall.

• External components: A mobile charger (MC) is connected to a non-invasive transmit coil, positioned over the implanted neuroregulator and secured in place using a transmit coil belt to charge and perform status checks on the neuroregulator. The MC is charged using an AC recharger. A laptop computer (CP) with proprietary software is used to control and upload data from the neuroregulator through the MC via the programmer cable. The CP is used by the clinician to change treatment parameters and assess battery recharging compliance. A torque wrench is used during the implant procedure to secure the leads into the neuroregulator.

Schedule of events following the baseline study visit include: implant, 2 week follow up, and 1, 3, 6, 9, and 12 month follow up visits. Enrolled subjects will also use the vBloc Achieve weight management program, which is a remote weight management counseling sessions with a registered dietitian to discuss healthy diet and exercise habits and weight loss goals.

The vBloc Now registry, together with vBloc Therapy and the vBloc Achieve weight management program, incorporates specific diets after the implant, routine remote counseling by an experienced registered dietitian, recommendations for physical activity, and tracking of weight, food intake, and fitness. The expectation is that patients participating in the vBloc Now registry, who comply with the diet and behavioral recommendations in combination with use of the Maestro device, will see an improvement in their overall health, whether it's related to weight loss, improvements in co-morbidities, or a better quality of life.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 125
• Est. completion date: May 31, 2019
• Est. primary completion date: February 1, 2019
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion criteria

1. Signed informed consent

2. Body mass index (BMI) = 40 kg/m2 to 45 kg/m2 or BMI = 35 kg/m2 to 39.9 kg/m2 with one or more obesity related co-morbid conditions

3. Females or males. Note: females of child-bearing potential must have a negative urine pregnancy test at Screen and also within 14 days of implant procedure followed by physician-approved contraceptive regimen for the duration of the study period.

4. At least 18 years of age

5. Failure to respond to supervised diet/exercise program(s) in which the subject was engaged within the last five years

6. Ability to complete all study visits and procedures

Exclusion criteria

1. Patients with cirrhosis of the liver, portal hypertension, or esophageal varices.

2. Patients with a large (>5cm) symptomatic hiatal hernia

3. Patients for whom magnetic resonance imaging (MRI) is planned

4. Patients at high risk for surgical complications

5. Patients who have a permanently implanted, electrical-powered medical device or gastrointestinal device or prosthesis (e.g. pacemakers, implanted defibrillators, neurostimulators)

6. Patients for whom shortwave, microwave, or therapeutic ultrasound diathermy is planned Note: Diathermy is any treatment that uses high-frequency electromagnetic radiation, electric currents, or ultrasonic waves to produce heat in body tissues. Patients absolutely CANNOT be treated with any type of shortwave, microwave, or therapeutic ultrasound diathermy device whether or not it is used to produce heat. These treatments should not be applied anywhere on the body.

7. Current medical condition that, in the opinion of the investigator, would make the subject unfit for surgery or that would be exacerbated by intentional weight loss. Some examples include diagnosis of cancer, recent heart attack, recent stroke or serious trauma.

Related Conditions & MeSH terms

• Obesity, Morbid

Intervention

Device:
• vBloc Maestro Rechargeable System
vBloc therapy consists of a neuromodulation device that delivers intermittent, controllable electrical blocking algorithms, to the intra-abdominal vagus nerve for the treatment of obesity.

Locations

Country	Name	City	State
United States	Sky Ridge	Lone Tree	Colorado
United States	Christiana Institute of Advanced Surgery	Newark	Delaware

Sponsors (1)

Lead Sponsor	Collaborator
EnteroMedics

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Real world experiences	health data pertaining to weight and obesity comorbidities	12 months following implant
Primary	Health economics	Collecting data to examine quality of life and work productivity after implant	12 months following implant