Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?

Obesity, Metabolically Benign Clinical Trial

— ChildObes  

Official title:

Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03354676
• Other study ID #: 12870
• Status: Completed
• Phase: N/A
• First received: September 12, 2017
• Last updated: November 26, 2017
• Start date: March 11, 2016
• Est. completion date: September 10, 2017

Study information

• Verified date: November 2017
• Source: Romanian Society of Anesthesia and Intensive Care
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population

Description:

The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.The current retrospective observational study was conducted at the "Louis Turcanu" Emergency Hospital Timisoara over a period of one year, from July 2013 and June 2014. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Endocrinology, Diabetology and Cardiology department.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 122
• Est. completion date: September 10, 2017
• Est. primary completion date: August 11, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 4 Years to 18 Years

Eligibility

Inclusion Criteria:

• obese children (BMI> 95th percentile)

Exclusion Criteria:

• obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

Related Conditions & MeSH terms

• Metabolic Syndrome X
• Obesity, Metabolically Benign

Intervention

Other:
• MetS+
Data processing from Patient Medical Files
• MetS-
Data processing from Patient Medical Files

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Alexandru Florin Rogobete	University of Medicine and Pharmacy "Victor Babes" Timisoara

References & Publications (3)

Bagherniya M, Khayyatzadeh SS, Heidari Bakavoli AR, Ferns GA, Ebrahimi M, Safarian M, Nematy M, Ghayour-Mobarhan M. Serum high-sensitive C-reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study. Ann Clin Biochem. 2017 Jan 1:4563217733286. doi: 10.1177/0004563217733286. [Epub ahead of print] — View Citation

Beyazit F, Ünsal MA. Obesity and insulin resistance are significant predictors of serum leptin levels. J Turk Ger Gynecol Assoc. 2017 Sep 1;18(3):158-159. doi: 10.4274/jtgga.2017.0027. — View Citation

López-Quintero A, García-Zapién AG, Flores-Martínez SE, Díaz-Burke Y, González-Sandoval CE, Lopez-Roa RI, Medina-Díaz E, Muñoz-Almaguer ML, Sánchez-Corona J. Contribution of polymorphisms in the LEP, LEPR and RETN genes on serum leptin and resistin levels in young adults from Mexico. Cell Mol Biol (Noisy-le-grand). 2017 Aug 30;63(8):10-18. doi: 10.14715/cmb/2017.63.8.3. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Defining obesity in the pediatric population	Measuring weight in kilograms and height in meters in order to calculate BMI and represent it on the percentile graph.	Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile.
Primary	Leptin changes in the obese children with metabolic syndrome	Evaluating leptin in the obese group with metabolic syndrome	Leptin levels were measured on day 1 of admission. Normal range was considered < 24ng/ml.
Primary	Adiponectin changes in the obese children with metabolic syndrome	Evaluating adiponectin in the obese group with metabolic syndrome	Adiponectin levels were measured on day 1 of admittance in children aged between 4 and18 years. Levels 4-26 mcg/ml were defined as normal values.
Primary	Assessing cardiovascular risk in the obese children with metabolic syndrome	Evaluating hsCRP in the obese group with metabolic syndrome	hsCRP levels were measured on day 1 of admittance in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l