Obese Clinical Trial
Official title:
Exercise Response in Humans With Obesity
NCT number | NCT05857150 |
Other study ID # | 22-012396 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | September 22, 2023 |
Est. completion date | July 2029 |
This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.
Status | Recruiting |
Enrollment | 120 |
Est. completion date | July 2029 |
Est. primary completion date | July 2029 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 45 Years |
Eligibility | Inclusion Criteria: - Obese men and women = 20 and = 45 years of age. Exclusion Criteria: - Diabetes or fasting plasma glucose >126 mg/dL - Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl) - Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment) - Renal failure (serum creatinine > 1.5mg/dl) - Chronic active liver disease defined as aspartate aminotransferase (AST)>144 IU/L or alanine transaminase (ALT) >165 IU/L) - Oral warfarin group medications or history of blood clotting disorders. - Smoking - Pregnancy or breastfeeding - Alcohol consumption greater than 2 glasses/day or other substance abuse - Untreated or uncontrolled hypothyroidism - Debilitating chronic disease (at the discretion of the investigators) |
Country | Name | City | State |
---|---|---|---|
United States | Mayo Clinic in Rochester | Rochester | Minnesota |
Lead Sponsor | Collaborator |
---|---|
Mayo Clinic |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in muscle protein synthesis | Skeletal muscle protein synthesis will be measured from the rate of incorporation of infused amino acids measured by mass spectrometry. | Baseline, post-exercise approximately 8 hours | |
Secondary | Change in mRNA expression of exercise responsive genes | Measure messenger ribonucleic acids (mRNAs) expression on exercise responsive genes | Baseline, post-exercise approximately 8 hours | |
Secondary | Change in expression and activation (phosphorylation) of signaling proteins | Phosphorylation is a common mechanism for the regulation of receptor function | Baseline, post-exercise approximately 8 hours |
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