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Efficacy and Safety Study of Combigan and 0.5% Timoptic in Normal Tension Glaucoma

Normal Tension Glaucoma Clinical Trial

Official title:
Randomized, Multicenter, Open-label, Parallel Group Study to Evaluate Efficacy and Safety of Combigan(Brimonidine/Timolol) and 0.5% Timoptic(Timolol) Ophthalmic Solutions in Normal Tension Glaucoma Patients

Clinical Trial Summary

Purpose To evaluate efficacy and safety of combigan(Brimonidine/Timolol) and 0.5% Timoptic (Timolol) ophthalmic solutions in normal tension glaucoma patients.

Clinical Trial Description

- Normal tension glaucoma (NTG) is the major type of glaucoma in Korea. (over 90% of glaucoma type)

- Brimonidine (selective alpha 2 adrenergic agonist): neuroprotection effect by suppression of aqueous humor production and increasement of uveoscleral outflow

- Timolol (non selective beta blocker): suppression effect of aqueous humor production

- Combigan (fixed combination of brimonidine & timolol): more lowering effect of intraocular pressure and enhancing the compliance of glaucoma patients ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01446497
Study type Interventional
Source Seoul National University Hospital
Contact Ki Ho Park, M.D., Ph.D.
Phone +82-2-2072-2438
Email kihopark@snu.ac.kr
Status Recruiting
Phase Phase 4
Start date October 2010
Completion date August 2012
View Details
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