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Clinical Trial Summary

This is a Phase I/II study designed to evaluate if experimental anti-TIGIT/anti-PD-1 bispecific antibody rilvegostomig (AZD2936) is safe, tolerable and efficacious in participants with Advanced or Metastatic Non-small Cell Lung Cancer.


Clinical Trial Description

This is a first-time-in-human (FTIH), open-label, multicenter, multi-part, dose-escalation and dose-expansion study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics, and efficacy of rilvegostomig (AZD2936) in adult participants with stage III unresectable or stage IV NSCLC. The study includes 4 parts: Part A (dose escalation) and Parts B-D (dose expansion). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04995523
Study type Interventional
Source AstraZeneca
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date September 14, 2021
Completion date November 27, 2025

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